Complementary and synergistic activities of anti-V3, CD4bs and CD4i antibodies derived from a single individual can cover a wide range of HIV-1 strains

被引：23

作者：

Valdez, Kristel Paola Ramirez ^{[1
]}

Kuwata, Takeo ^{[1
]}

Maruta, Yasuhiro ^{[1
]}

Tanaka, Kazuki ^{[1
]}

Alam, Muntasir ^{[1
]}

Yoshimura, Kazuhisa ^{[1
,2
]}

Matsushita, Shuzo ^{[1
]}

机构：

[1] Kumamoto Univ, Matsushita Project Lab, Ctr AIDS Res, Kumamoto, Japan

[2] Natl Inst Infect Dis, AIDS Res Ctr, Tokyo, Japan

来源：

VIROLOGY | 2015年 / 475卷

关键词：

HIV-1; Conventional antibodies; Neutralizing antibodies; Synergy; ADCC activity; HUMAN-IMMUNODEFICIENCY-VIRUS; NEUTRALIZING MONOCLONAL-ANTIBODIES; DEPENDENT CELLULAR CYTOTOXICITY; GP120 ENVELOPE GLYCOPROTEIN; MUCOSAL SHIV CHALLENGE; FUSION INHIBITOR T-20; ANTIRETROVIRAL THERAPY; MEDIATED CYTOTOXICITY; VACCINE DEVELOPMENT; TYROSINE SULFATION;

D O I：

10.1016/j.virol.2014.11.011

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Antibodies with modest neutralizing activity and narrow breadth are commonly elicited in HIV-1. Here, we evaluated the complementary and synergistic activities of a set of monoclonal antibodies (MAb) isolated from a single patient, directed to V3, CD4 binding site (CD4bs), and CD4 induced (CD4i) epitopes. Despite low somatic hypermutation percentages in the variable regions, these MAbs covered viral strains from subtypes B, C, A and CRF01_AE and transmitted/founder viruses in terms of binding, neutralizing and antibody-dependent cell-mediated cytotoxicity (ADCC) activities. In addition, a combination of the anti-V3 and CD4bs MAbs showed a synergistic effect over the neutralization of HIV-1(JR-FL). A humoral response from a single patient covered a wide range of viruses by complementary and synergistic activities of antibodies with different specificities. Inducing a set of narrow neutralizing antibodies, easier to induce than the broadly neutralizing antibodies, could be a strategy for developing an effective vaccine against HIV-1. (C) 2014 Elsevier Inc. All rights reserved.

引用

页码：187 / 203

页数：17

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