Bioavailability of Tea Catechins and Its Improvement

被引：233
作者：
Cai, Zhuo-Yu [1 ]
Li, Xu-Min [1 ]
Liang, Jin-Pei [2 ]
Xiang, Li-Ping [3 ]
Wang, Kai-Rong [4 ]
Shi, Yun-Long [1 ]
Yang, Rui [1 ]
Shi, Meng [1 ]
Ye, Jian-Hui [1 ]
Lu, Jian-Liang [1 ]
Zheng, Xin-Qiang [1 ]
Liang, Yue-Rong [1 ]
机构：
[1] Zhejiang Univ, Tea Res Inst, Hangzhou 310058, Zhejiang, Peoples R China
[2] Intellectual Property Off Lanshan Dist, Rizhao 543003, Peoples R China
[3] Natl Tea & Tea Prod Qual Supervis & Inspect Ctr G, Zunyi 563100, Peoples R China
[4] Ningbo Extens Stn Forestry & Special Technol, Ningbo 315012, Zhejiang, Peoples R China
来源：
MOLECULES | 2018年 / 23卷 / 09期
关键词：
Camellia sinensis; catechins; bioavailability; nanoparticle; interaction; IN-VITRO DIGESTION; (-)-EPIGALLOCATECHIN GALLATE EGCG; ORAL EPIGALLOCATECHIN GALLATE; GREEN-TEA; POLYPHENOL (-)-EPIGALLOCATECHIN-3-GALLATE; CHITOSAN NANOPARTICLES; DELIVERY-SYSTEM; CANCER CELLS; ANTIPROLIFERATIVE ACTIVITY; INTESTINAL TRANSPORT;
D O I：
10.3390/molecules23092346
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Many in vitro studies have shown that tea catechins had vevarious health beneficial effects. However, inconsistent results between in vitro and in vivo studies or between laboratory tests and epidemical studies are observed. Low bioavailability of tea catechins was an important factor leading to these inconsistencies. Research advances in bioavailability studies involving absorption and metabolic biotransformation of tea catechins were reviewed in the present paper. Related techniques for improving their bioavailability such as nanostructure-based drug delivery system, molecular modification, and co-administration of catechins with other bioactives were also discussed.
引用
收藏
页数：18
相关论文
共 116 条
[1]   Combined inhibitory effects of green tea polyphenols and selective cyclooxygenase-2 inhibitors on the growth of human prostate cancer cells both in vitro and in vivo [J].
Adhami, Vaqar Mustafa ;
Malik, Arshi ;
Zaman, Najia ;
Sarfaraz, Sami ;
Siddiqui, Imtiaz Ahmad ;
Syed, Deeba Nadeem ;
Afaq, Farrukh ;
Pasha, Farrukh Sierre ;
Saleem, Mohammad ;
Mukhtar, Hasan .
CLINICAL CANCER RESEARCH, 2007, 13 (05) :1611-1619
[2]   Nanoemulsion based delivery system for improved bioaccessibility and Caco-2 cell monolayer permeability of green tea catechins [J].
Bhushani, J. Anu ;
Karthik, P. ;
Anandharamakrishnan, C. .
FOOD HYDROCOLLOIDS, 2016, 56 :372-382
[3]   Contribution of presystemic hepatic extraction to the low oral bioavailability of green tea catechins in rats [J].
Cai, Y ;
Anavy, ND ;
Chow, HHS .
DRUG METABOLISM AND DISPOSITION, 2002, 30 (11) :1246-1249
[4]   Bioavailability of dietary doses of 3H-labelled tea antioxidants (+)-catechin and (-)-epicatechin in rat [J].
Catterall, F ;
King, LJ ;
Clifford, MN ;
Ioannides, C .
XENOBIOTICA, 2003, 33 (07) :743-753
[5]  
Cavet ME, 2011, MOL VIS, V17, P533
[6]   Novel epigallocatechin gallate (EGCG) analogs activate AMP-activated protein kinase pathway and target cancer stem cells [J].
Chen, Di ;
Pamu, Sreedhar ;
Cui, Qiuzhi ;
Chan, Tak Hang ;
Dou, Q. Ping .
BIOORGANIC & MEDICINAL CHEMISTRY, 2012, 20 (09) :3031-3037
[7]  
Chen LS, 1997, DRUG METAB DISPOS, V25, P1045
[8]   Peracetylated (-)-epigallocatechin-3-gallate (AcEGCG) potently prevents skin carcinogenesis by suppressing the PKD1-dependent signaling pathway in CD34+ skin stem cells and skin tumors [J].
Chiou, Yi-Shiou ;
Sang, Shengmin ;
Cheng, Kuang-Hung ;
Ho, Chi-Tang ;
Wang, Ying-Jan ;
Pan, Min-Hsiung .
CARCINOGENESIS, 2013, 34 (06) :1315-1322
[9]   Peracetylated (-)-Epigallocatechin-3-gallate (AcEGCG) Potently Suppresses Dextran Sulfate Sodium-Induced Colitis and Colon Tumorigenesis in Mice [J].
Chiou, Yi-Shiou ;
Ma, Nianhan Jia-Lin ;
Sang, Shengmin ;
Ho, Chi-Tang ;
Wang, Ying-Jan ;
Pan, Min-Hsiung .
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2012, 60 (13) :3441-3451
[10]   Effects of Oral Epigallocatechin Gallate on the Pharmacokinetics of Nicardipine in Rats [J].
Choi, Jun-Shik ;
Burm, Jin-Pil .
ARCHIVES OF PHARMACAL RESEARCH, 2009, 32 (12) :1721-1725
12345678910