Th9 lymphocytes: A recent history from IL-9 to its potential role in rheumatic diseases

被引：24

作者：

Gerardo Rojas-Zuleta, Wilmer ^{[1
]}

Vasquez, Gloria ^{[2
]}

机构：

[1] Univ Antioquia, Medellin, Colombia

[2] Univ Antioquia, Fac Med, Inst Invest Med, Grp Inmunol Celular & Inmunogenet, Kr 53 61-30 Lab 510, Medellin, Colombia

来源：

AUTOIMMUNITY REVIEWS | 2016年 / 15卷 / 07期

关键词：

Th9; lymphocytes; Interleukin-9; Rheumatoid arthritis; Systemic lupus erythematous; Systemic sclerosis; INTERLEUKIN-9-PRODUCING T-CELLS; HELPER; 9; CELLS; TRANSCRIPTION FACTOR; GROWTH-FACTOR; AIRWAY INFLAMMATION; SYSTEMIC-SCLEROSIS; TGF-BETA; LINEAGE COMMITMENT; T(H)9 CELLS; DIFFERENTIATION;

D O I：

10.1016/j.autrev.2016.02.020

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Various subtypes of effector T cells have been described up to date, and each one has its specific immunological function and a defined cytokine secretion profile. Th9 lymphocytes, recently described, are characterized by a high IL-9 expression. Their differentiation requires the integration of IL-4 and TGF-p signaling pathways and the coordinated participation of multiple transcription factors. Their role has been mainly found in immunity against parasites and in allergic inflammatory processes. Nevertheless, they have been implicated in processes as autoimmunity, cancer and recently in rheumatic diseases. The objective of this review is to describe the discovery of this cellular subtype, its differentiation, expression regulation and its potential role in rheumatic diseases. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：649 / 655

页数：7

共 73 条

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