Th9 lymphocytes: A recent history from IL-9 to its potential role in rheumatic diseases

被引：24
作者：
Gerardo Rojas-Zuleta, Wilmer [1 ]
Vasquez, Gloria [2 ]
机构：
[1] Univ Antioquia, Medellin, Colombia
[2] Univ Antioquia, Fac Med, Inst Invest Med, Grp Inmunol Celular & Inmunogenet, Kr 53 61-30 Lab 510, Medellin, Colombia
来源：
AUTOIMMUNITY REVIEWS | 2016年 / 15卷 / 07期
关键词：
Th9; lymphocytes; Interleukin-9; Rheumatoid arthritis; Systemic lupus erythematous; Systemic sclerosis; INTERLEUKIN-9-PRODUCING T-CELLS; HELPER; 9; CELLS; TRANSCRIPTION FACTOR; GROWTH-FACTOR; AIRWAY INFLAMMATION; SYSTEMIC-SCLEROSIS; TGF-BETA; LINEAGE COMMITMENT; T(H)9 CELLS; DIFFERENTIATION;
D O I：
10.1016/j.autrev.2016.02.020
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Various subtypes of effector T cells have been described up to date, and each one has its specific immunological function and a defined cytokine secretion profile. Th9 lymphocytes, recently described, are characterized by a high IL-9 expression. Their differentiation requires the integration of IL-4 and TGF-p signaling pathways and the coordinated participation of multiple transcription factors. Their role has been mainly found in immunity against parasites and in allergic inflammatory processes. Nevertheless, they have been implicated in processes as autoimmunity, cancer and recently in rheumatic diseases. The objective of this review is to describe the discovery of this cellular subtype, its differentiation, expression regulation and its potential role in rheumatic diseases. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码：649 / 655
页数：7
相关论文
共 73 条
[61]   CLONING AND CHARACTERIZATION OF A CDNA FOR A NEW MOUSE T-CELL GROWTH-FACTOR (P40) [J].
VANSNICK, J ;
GOETHALS, A ;
RENAULD, JC ;
VANROOST, E ;
UYTTENHOVE, C ;
RUBIRA, MR ;
MORITZ, RL ;
SIMPSON, RJ .
JOURNAL OF EXPERIMENTAL MEDICINE, 1989, 169 (01) :363-368
[62]   Transforming growth factor-β 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset [J].
Veldhoen, Marc ;
Uyttenhove, Catherine ;
van Snick, Jacques ;
Helmby, Helena ;
Westendorf, Astrid ;
Buer, Jan ;
Martin, Bruno ;
Wilhelm, Christoph ;
Stockinger, Brigitta .
NATURE IMMUNOLOGY, 2008, 9 (12) :1341-1346
[63]   Regulation of human Th9 differentiation by type I interferons and IL-21 [J].
Wong, Michael T. ;
Ye, Jessica J. ;
Alonso, Michael N. ;
Landrigan, Angela ;
Cheung, Regina K. ;
Engleman, Edgar ;
Utz, Paul J. .
IMMUNOLOGY AND CELL BIOLOGY, 2010, 88 (06) :624-631
[64]   OX40 signaling favors the induction of TH9 cells and airway inflammation [J].
Xiao, Xiang ;
Balasubramanian, Savithri ;
Liu, Wentao ;
Chu, Xiufeng ;
Wang, Haibin ;
Taparowsky, Elizabeth J. ;
Fu, Yang-Xin ;
Choi, Yongwon ;
Walsh, Matthew C. ;
Li, Xian Chang .
NATURE IMMUNOLOGY, 2012, 13 (10) :981-990
[65]   Th9: A New Player in Asthma Pathogenesis?? [J].
Xing, Junchao ;
Wu, Yuzhang ;
Ni, Bing .
JOURNAL OF ASTHMA, 2011, 48 (02) :115-125
[66]   Serum Interleukin 9 Levels Are Increased in Patients with Systemic Sclerosis: Association with Lower Frequency and Severity of Pulmonary Fibrosis [J].
Yanaba, Koichi ;
Yoshizaki, Ayumi ;
Asano, Yoshihide ;
Kadono, Takafumi ;
Sato, Shinichi .
JOURNAL OF RHEUMATOLOGY, 2011, 38 (10) :2193-2197
[67]   Interleukin-9 Is Associated with Elevated Anti-Double-Stranded DNA Antibodies in Lupus-Prone Mice [J].
Yang, Ji ;
Li, Qiao ;
Yang, Xue ;
Li, Ming .
MOLECULAR MEDICINE, 2015, 21 :364-370
[68]  
YANG YC, 1989, BLOOD, V74, P1880
[69]   Interleukin-9 Is Required for Allergic Airway Inflammation Mediated by the Cytokine TSLP [J].
Yao, Weiguo ;
Zhang, Yanlu ;
Jabeen, Rukhsana ;
Nguyen, Evelyn T. ;
Wilkes, David S. ;
Tepper, Robert S. ;
Kaplan, Mark H. ;
Zhou, Baohua .
IMMUNITY, 2013, 38 (02) :360-372
[70]   Predisposition to the development of IL-9-secreting T cells in atopic infants [J].
Yao, Weiguo ;
Tepper, Robert S. ;
Kaplan, Mark H. .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2011, 128 (06) :1357-1360
12345678