Prognostic value of clinicopathological parameters in head and neck squamous cell carcinoma: A prospective analysis

被引:82
作者
Janot, F
Klijanienko, J
Russo, A
Mamet, JP
deBraud, F
ElNaggar, AK
Pignon, JP
Luboinski, B
Cvitkovic, E
机构
[1] INST GUSTAVE ROUSSY, DEPT ONCOL, F-94805 VILLEJUIF, FRANCE
[2] INST GUSTAVE ROUSSY, DEPT HEAD & NECK SURG, F-94805 VILLEJUIF, FRANCE
[3] INST GUSTAVE ROUSSY, DEPT PATHOL, F-94805 VILLEJUIF, FRANCE
[4] INST GUSTAVE ROUSSY, DEPT BIOSTAT, F-94805 VILLEJUIF, FRANCE
[5] MD ANDERSON CANC CTR, DEPT PATHOL, HOUSTON, TX 77030 USA
关键词
head and neck cancer; prognostic factors; ploidy; grading; metastatic risk;
D O I
10.1038/bjc.1996.92
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The prognostic weight of histological and biological factors was compared with that of known clinical prognostic factors in a population of 108 consecutive previously untreated patients with head and neck squamous cell carcinoma. Parameters studied were: tumour vascularisation, mitotic index, histological differentiation, nuclear grade, keratinisation, desmoplasia, growth pattern, inflammation, tumour emboli in peripheral vessels, keratins 6, 13, 19 immunohistochemical expression, cytofluorometric ploidy and S-phase. In multivariate analysis (Cox), only age and nodal status had a significant impact on overall survival, whereas T stage was the only significant factor associated with locoregional failure. The cumulative incidence of metastases was correlated not only with age, T and N stage, but also with histological differentiation. All the other histological and biological factors studied failed to provide further prognostic information. These findings may help to select patients with high metastatic risk.
引用
收藏
页码:531 / 538
页数:8
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