The current status of CZT SPECT myocardial blood flow and reserve assessment: Tips and tricks

被引:35
作者
Zavadovsky, Konstantin V. [1 ,2 ]
Mochula, Andrew V. [1 ]
Maltseva, Alina N. [1 ]
Shipulin, Vladimir V. [1 ]
Sazonova, Svetlana I. [1 ]
Gulya, Marina O. [1 ]
Liga, Ricardo [3 ]
Gimelli, Alessia [4 ]
机构
[1] Russian Acad Sci, Tomsk Natl Res Med Ctr, Cardiol Res Inst, Kievskaya Str 111A, Tomsk 634012, Russia
[2] Siberian State Med Univ, Tomsk, Russia
[3] Univ Pisa, Pisa, Italy
[4] CNR Gabriele Monasterio, Fdn Toscana, Pisa, Italy
关键词
SPECT; CZT; CAD; Myocardial ischemia; Myocardial blood flow; Myocardial flow reserve;
D O I
10.1007/s12350-021-02620-y
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Cardiac PET-derived measurements of myocardial blood flow (MBF) and myocardial flow reserve (MFR) are proven robust indexes of the severity of coronary artery disease (CAD). They facilitate the diagnosis of diffuse epicardial and microvascular disease and are also of prognostic significance. However, low availability and high cost have limited their wide clinical implementation. Over the last 15 years, cadmium zinc telluride (CZT)-based detectors have been implemented into SPECT imaging devices. Myocardial perfusion scintigraphy can be performed faster and with less radiation exposure as compared with standard gamma cameras. Rapid dynamic SPECT studies with higher count rates can be performed. This technological breakthrough has renewed the interest in SPECT MBF assessment in patients with CAD. Currently, two cardiac-centered CZT gamma cameras are available commercially-Discovery NM530c and D-SPECT. They differ in parameters such as collimator design, number of detectors, sensitivity, spatial resolution and image reconstruction. A number of publications have focused on the feasibility of dynamic CZT SPECT and on the correlation with cardiac PET and invasive coronary angiography measurements of fractional flow reserve. Current study reviews the present status of MBF and MFR assessment with CZT SPECT. It also aims to provide an overview of specific issues related to acquisition, processing and interpretation of quantitative studies in patients with CAD.
引用
收藏
页码:3137 / 3151
页数:15
相关论文
共 72 条
[61]   Estimation of coronary flow reserve with the use of dynamic planar and SPECT images of Tc-99m tetrofosmin [J].
Sugihara, H ;
Yonekura, Y ;
Kataoka, K ;
Fukai, D ;
Kitamura, N ;
Taniguchi, Y .
JOURNAL OF NUCLEAR CARDIOLOGY, 2001, 8 (05) :575-579
[62]   Angiographic Versus Functional Severity of Coronary Artery Stenoses in the FAME Study Fractional Flow Reserve Versus Angiography in Multivessel Evaluation [J].
Tonino, Pim A. L. ;
Fearon, William F. ;
De Bruyne, Bernard ;
Oldroyd, Keith G. ;
Leesar, Massoud A. ;
Lee, Peter N. Ver ;
MacCarthy, Philip A. ;
van't Veer, Marcel ;
Pijls, Nico H. J. .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2010, 55 (25) :2816-2821
[63]   Myocardial perfusion scintigraphy: the evidence - A consensus conference organised by the British Cardiac Society, the British Nuclear Cardiology Society and the British Nuclear Medicine Society, endorsed by the Royal College of Physicians of London and the Royal College of Radiologists [J].
Underwood, SR ;
Anagnostopoulos, C ;
Cerqueira, M ;
Ell, PJ ;
Flint, EJ ;
Harbinson, M ;
Kelion, AD ;
Al-Mohammad, A ;
Prvulovich, EM ;
Shaw, LJ ;
Tweddel, AC .
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2004, 31 (02) :261-291
[64]   Physiological Basis and Long-Term Clinical Outcome of Discordance Between Fractional Flow Reserve and Coronary Flow Velocity Reserve in Coronary Stenoses of Intermediate Severity [J].
van de Hoef, Tim P. ;
van Lavieren, Martijn A. ;
Damman, Peter ;
Delewi, Ronak ;
Piek, Martijn A. ;
Chamuleau, Steven A. J. ;
Voskuil, Michiel ;
Henriques, Jose P. S. ;
Koch, Karel T. ;
de Winter, Robbert J. ;
Spaan, Jos A. E. ;
Siebes, Maria ;
Tijssen, Jan G. P. ;
Meuwissen, Martijn ;
Piek, Jan J. .
CIRCULATION-CARDIOVASCULAR INTERVENTIONS, 2014, 7 (03) :301-311
[65]   Variation in Quantitative Myocardial Perfusion Due to Arterial Input Selection [J].
Vasquez, Andres F. ;
Johnson, Nils P. ;
Gould, K. Lance .
JACC-CARDIOVASCULAR IMAGING, 2013, 6 (05) :559-568
[66]   Test-Retest Precision of Myocardial Blood Flow Measurements With 99mTc-Tetrofosmin and Solid-State Detector Single Photon Emission Computed Tomography [J].
Wells, R. Glenn ;
Radonjic, Ivana ;
Clackdoyle, Duncan ;
Do, Jeffrey ;
Marvin, Brian ;
Carey, Clare ;
deKemp, Robert A. ;
Ruddy, Terrence D. .
CIRCULATION-CARDIOVASCULAR IMAGING, 2020, 13 (02) :E009769
[67]   Optimization of SPECT Measurement of Myocardial Blood Flow with Corrections for Attenuation, Motion, and Blood Binding Compared with PET [J].
Wells, R. Glenn ;
Marvin, Brian ;
Poirier, Marlie ;
Renaud, Jennifer ;
dekemp, Robert A. ;
Ruddy, Terrence D. .
JOURNAL OF NUCLEAR MEDICINE, 2017, 58 (12) :2013-2019
[68]   Dynamic SPECT Measurement of Absolute Myocardial Blood Flow in a Porcine Model [J].
Wells, R. Glenn ;
Timmins, Rachel ;
Klein, Ran ;
Lockwood, Julia ;
Marvin, Brian ;
deKemp, Robert A. ;
Wei, Lihui ;
Ruddy, Terrence D. .
JOURNAL OF NUCLEAR MEDICINE, 2014, 55 (10) :1685-1691
[69]   Investigation of dynamic SPECT measurements of the arterial input function in human subjects using simulation, phantom and human studies [J].
Winant, Celeste D. ;
Aparici, Carina Mari ;
Zelnik, Yuval R. ;
Reutter, Bryan W. ;
Sitek, Arkadiusz ;
Bacharach, Stephen L. ;
Gullberg, Grant T. .
PHYSICS IN MEDICINE AND BIOLOGY, 2012, 57 (02) :375-393
[70]  
Yoshida K, 1996, J NUCL MED, V37, P1701