Bronsted Acid Catalyzed Peptide Synthesis through Azlactone R ings

被引：12
|
作者：
De Castro, Pedro P. [1 ]
Dos Santos, Igor F. [1 ]
Amarante, Giovanni W. [1 ]
机构：
[1] Univ Fed Juiz de Fora, Dept Chem, Juiz de Fora, MG, Brazil
来源：
CURRENT ORGANIC SYNTHESIS | 2016年 / 13卷 / 03期
关键词：
Azlactones; peptides; amino acids; organocatalysis; Bronted acid; ( plus /-)-camphorsulfonic acid; ASYMMETRIC CATALYSIS; ORGANIC-SYNTHESIS; AMINO-ACIDS; ORGANOCATALYSIS; ACTIVATION; DESIGN;
D O I：
10.2174/1570179413999151211114542
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Bronsted acid catalyzed azlactone ring opening by amino acids leading to the synthesis of dipeptides is presented. Eleven compounds were synthesized in good to excellent isolated yields. Catalyst loading revealed that 5.0 mol % of (+/-)-CSA as an organocatalyst, under room temperature for 24 h, was suitable to promote this transformation.
引用
收藏
页码：440 / 444
页数：5
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