Effects of bariatric surgery on pericardial ectopic fat depositions and cardiovascular function

ObjectiveCardiac ectopic fat depositions are thought to play a role in the pathogenesis of cardiovascular disease (CVD), the main cause of death in patients with type 2 diabetes. Diet-induced weight loss results in a decrease in cardiac ectopic fat stores, however if this is the same for surgically induced weight loss is less clear. Therefore, we assessed myocardial triglyceride (TG) content, pericardial fat and cardiac function in obese patients with insulin-dependent type 2 diabetes before and 16weeks after Roux-en-Y gastric bypass (RYGB) surgery. PatientsTen obese patients with insulin-dependent type 2 diabetes [40% male, age 53789years (meanSD)] scheduled to undergo RYGB surgery were included. MeasurementsEctopic fat accumulation and cardiovascular function were assessed with magnetic resonance (MR) imaging and myocardial TG content with MR spectroscopy before and 16weeks after RYGB surgery. ResultsBody mass index decreased from 413 +/- 43 at baseline to 341 +/- 28kg/m(2) (P<0001) after 16weeks. Glycemic control improved as well [HbA1c: 78 +/- 11 to 68 +/- 13% (62 +/- 12 to 51 +/- 14mm) (P<005)]. We did not observe an effect of the RYGB surgery on myocardial TG content, cardiac function or pulse wave velocity. There was a greater relative decrease in visceral (-355 +/- 96%) as compared to subcutaneous fat volume (-250 +/- 63%) and in paracardial (-173 +/- 172%) as compared to epicardial fat volume (-64 +/- 60%). ConclusionsThis study shows that surgical-induced weight loss leads to a larger decrease in paracardial than epicardial fat. Myocardial TG and cardiovascular function did not change.