Selective α7 nicotinic acetylcholine receptor ligands for the treatment of neuropsychiatric diseases

被引：20

作者：

Broad, Lisa M. ^{[1
]}

Sher, Emanuele ^{[1
]}

Astles, Peter C. ^{[1
]}

Zwart, Ruud ^{[1
]}

O'Neill, Michael J. ^{[1
]}

机构：

[1] Eli Lilly & Co, Lilly Res Ctr Ltd, Windlesham GU20 6PH, Surrey, England

来源：

DRUGS OF THE FUTURE | 2007年 / 32卷 / 02期

关键词：

D O I：

10.1358/dof.2007.032.02.1064020

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Recent developments have yielded a number of selective alpha 7 nicotinic acetylcholine receptor (nAChR) ligands allowing the critical evaluation of alpha 7 nAChRs as targets for the treatment of neuropsychiatric and neurodegenerative diseases. We review the in vitro and in vivo profiles of these alpha 7 nAChR-selective ligands and preliminary data on their use in man.

引用

页码：161 / 170

页数：10

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