Primers on Molecular Pathways - Ion Channels: Key Regulators of Pancreatic Physiology

被引：1

作者：

Banales, Jesus M. ^{[2
,3
]}

Gradilone, Sergio A. ^{[1
]}

机构：

[1] Mayo Clin, Coll Med, Div Gastroenterol & Hepatol, Dept Internal Med, Rochester, MN 55905 USA

[2] Univ Navarra, Sch Med, Div Gene Therapy & Hepatol, Mol Genet Lab, E-31080 Pamplona, Spain

[3] Univ Navarra, CIMA, E-31080 Pamplona, Spain

来源：

PANCREATOLOGY | 2009年 / 9卷 / 05期

关键词：

Primers on molecular pathways; Ion channels; Key regulators of pancreatic physiology; CYSTIC-FIBROSIS; EXOCRINE PANCREAS; DUCT CELLS; CFTR; SECRETION; DISEASE; CHANNELOPATHIES; MECHANISMS;

D O I：

10.1159/000221382

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Ion transport across the cellular plasma membrane is important in almost every physiological process. This phenomenon is driven by the coordinated action of carriers, pumps and channels, which move ions in and out the cells and between different organelles. Ion channels are transmembrane proteins that provide a continuous aqueous pore through which ions can selectively move. The interest in these molecules has increased due to the recognition of diverse pathologies related with mutations in genes encoding these transmembrane proteins, now known as channelopathies. Ion channels play a variety of functions in the pancreas. Here, we briefly describe ion transport characteristics as well as their role in pancreas physiology and pathophysiology. Copyright (C) 2009 S. Karger AG, Basel and IAP

引用

页码：556 / 559

页数：4

共 18 条

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