ALDEHYDE DEHYDROGENASE-2 ACTIVATION BY ALDA-1 DECREASES MITOCHONDRIAL DEPOLARIZATION AND CELL DEATH AFTER ACETAMINOPHEN OVERDOSE

被引：0
|
作者：
Wimborne, Hereward [1 ,2 ]
Hu, Jiangting [1 ,2 ]
Takemoto, Kenji [1 ,2 ]
Nga Nguyen [3 ]
Jaeschke, Hartmut [4 ]
Lemasters, John J. [1 ,2 ,5 ,6 ]
Zhong, Zhi [1 ]
机构：
[1] Med Univ South Carolina, Drug Discovery & Biomed Sci, Charleston, SC 29425 USA
[2] Med Univ South Carolina, Ctr Cell Death Injury & Regenerat, Charleston, SC 29425 USA
[3] Univ Kansas, Med Ctr, Pharmacol Toxicol & Therapeut, Lawrence, KS 66045 USA
[4] Univ Kansas, Med Ctr, Dept Pharmacol Toxicol & Therapeut, Lawrence, KS 66045 USA
[5] Med Univ South Carolina, Hollings Canc Ctr, Charleston, SC 29425 USA
[6] Med Univ South Carolina, Biochem & Mol Biol, Charleston, SC 29425 USA
来源：
HEPATOLOGY | 2019年 / 70卷
关键词：
D O I：
暂无
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
2062
引用
收藏
页码：1225A / 1226A
页数：2
相关论文
共 50 条
  • [1] Aldehyde dehydrogenase-2 activation decreases acetaminophen hepatotoxicity by prevention of mitochondrial depolarization
    Wimborne, Hereward J.
    Hu, Jiangting
    Takemoto, Kenji
    Nguyen, Nga T.
    Jaeschke, Hartmut
    Lemasters, John J.
    Zhong, Zhi
    TOXICOLOGY AND APPLIED PHARMACOLOGY, 2020, 396
  • [2] Aldehyde dehydrogenase-2 activation by Alda-1 decreases necrosis and fibrosis after bile duct ligation in mice
    Wimborne, Hereward J.
    Takemoto, Kenji
    Woster, Patrick M.
    Rockey, Don C.
    Lemasters, John J.
    Zhong, Zhi
    FREE RADICAL BIOLOGY AND MEDICINE, 2019, 145 : 136 - 145
  • [3] Effects of Alda-1, an Aldehyde Dehydrogenase-2 Agonist, on Hypoglycemic Neuronal Death
    Ikeda, Tetsuhiko
    Takahashi, Tetsuya
    Tsujita, Mika
    Kanazawa, Masato
    Toriyabe, Masafumi
    Koyama, Misaki
    Itoh, Kosuke
    Nakada, Tsutomu
    Nishizawa, Masatoyo
    Shimohata, Takayoshi
    PLOS ONE, 2015, 10 (06):
  • [4] Characterization of the East Asian Variant of Aldehyde Dehydrogenase-2 BIOACTIVATION OF NITROGLYCERIN AND EFFECTS OF Alda-1
    Beretta, Matteo
    Gorren, Antonius C. F.
    Wenzl, M. Verena
    Weis, Robert
    Russwurm, Michael
    Koesling, Doris
    Schmidt, Kurt
    Mayer, Bernd
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (02) : 943 - 952
  • [5] Alda-1 modulates the kinetic properties of mitochondrial aldehyde dehydrogenase (ALDH2)
    Belmont-Diaz, Javier A.
    Yoval-Sanchez, Belem
    Calleja-Castaneda, Luis F.
    Pardo Vazquez, Juan P.
    Rodriguez-Zavala, Jose S.
    FEBS JOURNAL, 2016, 283 (19) : 3637 - 3650
  • [6] Pharmacological activation of aldehyde dehydrogenase 2 by Alda-1 reverses alcohol- induced hepatic steatosis and cell death in mice
    Zhong, Wei
    Zhang, Wenliang
    Li, Qiong
    Xie, Guoxiang
    Sun, Qian
    Sun, Xiuhua
    Tan, Xiaobing
    Sun, Xinguo
    Jia, Wei
    Zhou, Zhanxiang
    JOURNAL OF HEPATOLOGY, 2015, 62 (06) : 1375 - 1381
  • [7] The impact of mitochondrial aldehyde dehydrogenase (ALDH2) activation by Alda-1 on the behavioral and biochemical disturbances in animal model of depression
    Stachowicz, Aneta
    Glombik, Katarzyna
    Olszanecki, Rafal
    Basta-Kaim, Agnieszka
    Suski, Maciej
    Lason, Wladyslaw
    Korbut, Ryszard
    BRAIN BEHAVIOR AND IMMUNITY, 2016, 51 : 144 - 153
  • [8] THE EFFECT OF MITOCHONDRIAL ALDEHYDE DEHYDROGENASE (ALDH2) ACTIVATION BY ALDA-1 IN THE PRENATALLY STRESSED RATS: BEHAVIORAL, MOLECULAR AND PROTEOMIC DATA
    Stachowicz, A.
    Glombik, K.
    Suski, M.
    Basta-Kaim, A.
    Olszanecki, R.
    Korbut, R.
    BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2014, 115 : 217 - 217
  • [9] Treatment of cardiomyocytes isolated from left ventricular myocardium of dogs with chronic heart failure with ALDA-1, an activator of aldehyde dehydrogenase-2, improves mitochondrial function
    Sabbah, H.
    Singh-Gupta, V.
    Gupta, R. C.
    Castle, K.
    Zhang, K.
    Xu, J.
    EUROPEAN HEART JOURNAL, 2023, 44
  • [10] Mitochondrial Aldehyde Dehydrogenase Activation by Alda-1 Inhibits Atherosclerosis and Attenuates Hepatic Steatosis in Apolipoprotein E-Knockout Mice
    Stachowicz, Aneta
    Olszanecki, Rafal
    Suski, Maciej
    Wisniewska, Anna
    Toton-Zuranska, Justyna
    Madej, Jozef
    Jawien, Jacek
    Bialas, Magdalena
    Okon, Krzysztof
    Gajda, Mariusz
    Glombik, Katarzyna
    Basta-Kaim, Agnieszka
    Korbut, Ryszard
    JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2014, 3 (06):
12345