Role of microRNAs in obesity and the metabolic syndrome

被引：171

作者：

Heneghan, H. M. ^{[1
]}

Miller, N. ^{[1
]}

Kerin, M. J. ^{[1
]}

机构：

[1] Natl Univ Ireland, Dept Surg, Galway Clin Sci Inst, Galway, Ireland

来源：

OBESITY REVIEWS | 2010年 / 11卷 / 05期

关键词：

Adipogenesis; biomarkers; metabolic syndrome; microRNAs; obesity; NEUROTROPHIC FACTOR; LIPID-METABOLISM; ADIPOSE-TISSUE; IN-VIVO; GLUCOSE; EXPRESSION; CANCER; BRAIN; TARGETS; MIRNAS;

D O I：

10.1111/j.1467-789X.2009.00659.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

P>Obesity and the metabolic syndrome are major public health concerns, and present a formidable therapeutic challenge. Many patients remain recalcitrant to conventional lifestyle changes and medical therapies. Bariatric surgery has made laudable progress in the treatment of obesity and its related metabolic disorders, yet carries inherent risks. Unravelling the molecular mechanisms of metabolic disorders is essential in order to develop novel, valid therapeutic strategies. Mi(cro)RNAs play important regulatory roles in a variety of biological processes including adipocyte differentiation, metabolic integration, insulin resistance and appetite regulation. Investigation of these molecules and their genetic targets may potentially identify new pathways involved in complex metabolic disease processes, improving our understanding of metabolic disorders and influence future approaches to the treatment of obesity. This review discusses the role of miRNAs in obesity and related components of the metabolic syndrome, and highlights the potential of using miRNAs as novel biomarkers and therapeutic targets for these diseases.

引用

页码：354 / 361

页数：8

共 50 条

[1] MicroRNA-124a regulates Foxa2 expression and intracellular signaling in pancreatic β-cell lines [J].

Baroukh, Nadine ;

Ravier, Magalie A. ;

Loder, Merewyn K. ;

Hill, Elaine V. ;

Bounacer, Ali ;

Scharfmann, Raphael ;

Rutter, Guy A. ;

Van Obberghen, Emmanuel .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (27) :19575-19588

[2] MicroRNAs: Genomics, biogenesis, mechanism, and function (Reprinted from Cell, vol 116, pg 281-297, 2004) [J].

Bartel, David P. .

CELL, 2007, 131 (04) :11-29

[3] Phylogenetic shadowing and computational identification of human microRNA genes [J].

Berezikov, E ;

Guryev, V ;

van de Belt, J ;

Wienholds, E ;

Plasterk, RHA ;

Cuppen, E .

CELL, 2005, 120 (01) :21-24

[4] Molecular therapy of obesity and diabetes by a physiological autoregulatory approach [J].

Cao, Lei ;

Lin, En-Ju D. ;

Cahill, Michael C. ;

Wang, Chuansong ;

Liu, Xianglan ;

During, Matthew J. .

NATURE MEDICINE, 2009, 15 (04) :447-454

[5] Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases [J].

Chen, Xi ;

Ba, Yi ;

Ma, Lijia ;

Cai, Xing ;

Yin, Yuan ;

Wang, Kehui ;

Guo, Jigang ;

Zhang, Yujing ;

Chen, Jiangning ;

Guo, Xing ;

Li, Qibin ;

Li, Xiaoying ;

Wang, Wenjing ;

Zhang, Yan ;

Wang, Jin ;

Jiang, Xueyuan ;

Xiang, Yang ;

Xu, Chen ;

Zheng, Pingping ;

Zhang, Juanbin ;

Li, Ruiqiang ;

Zhang, Hongjie ;

Shang, Xiaobin ;

Gong, Ting ;

Ning, Guang ;

Wang, Jun ;

Zen, Ke ;

Zhang, Junfeng ;

Zhang, Chen-Yu .

CELL RESEARCH, 2008, 18 (10) :997-1006

[6] A truth serum for cancer - microRNAs have major potential as cancer biomarkers [J].

Chin, Lena J. ;

Slack, Frank J. .

CELL RESEARCH, 2008, 18 (10) :983-984

[7] miR-375 targets 3'-phosphoinositide-dependent protein kinase-1 and regulates glucose-induced biological responses in pancreatic β-cells [J].

El Ouaamari, Abdelfattah ;

Baroukh, Nadine ;

Martens, Geert A. ;

Lebrun, Patricia ;

Pipeleers, Daniel ;

van Obberghen, Emmanuel .

DIABETES, 2008, 57 (10) :2708-2717

[8] LNA-mediated microRNA silencing in non-human primates [J].

Elmen, Joacim ;

Lindow, Morten ;

Schutz, Sylvia ;

Lawrence, Matthew ;

Petri, Andreas ;

Obad, Susanna ;

Lindholm, Marie ;

Hedtjarn, Maj ;

Hansen, Henrik Frydenlund ;

Berger, Urs ;

Gullans, Steven ;

Kearney, Phil ;

Sarnow, Peter ;

Straarup, Ellen Marie ;

Kauppinen, Sakari .

NATURE, 2008, 452 (7189) :896-U10

[9] miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting [J].

Esau, C ;

Davis, S ;

Murray, SF ;

Yu, XX ;

Pandey, SK ;

Pear, M ;

Watts, L ;

Booten, SL ;

Graham, M ;

McKay, R ;

Subramaniam, A ;

Propp, S ;

Lollo, BA ;

Freier, S ;

Bennett, CF ;

Bhanot, S ;

Monia, BP .

CELL METABOLISM, 2006, 3 (02) :87-98

[10] MicroRNA-143 regulates adipocyte differentiation [J].

Esau, C ;

Kang, XL ;

Peralta, E ;

Hanson, E ;

Marcusson, EG ;

Ravichandran, LV ;

Sun, YQ ;

Koo, S ;

Perera, RJ ;

Jain, R ;

Dean, NM ;

Freier, SM ;

Bennett, CF ;

Lollo, B ;

Griffey, R .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (50) :52361-52365

← 1 2 3 4 5 →