Intestinal Microbiota-Produced Trimethylamine-N-Oxide and Its Association With Coronary Stenosis and HIV Serostatus

被引：27

作者：

Miller, P. Elliott ^{[1
]}

Haberlen, Sabina A. ^{[2
]}

Brown, Todd T. ^{[1
]}

Margolick, Joseph B. ^{[2
,3
]}

DiDonato, Joseph A. ^{[4
]}

Hazen, Stanley L. ^{[4
]}

Witt, Mallory D. ^{[5
]}

Kingsley, Lawrence A. ^{[6
]}

Palella, Frank J., Jr. ^{[7
]}

Budoff, Matthew ^{[5
]}

Jacobson, Lisa P. ^{[2
]}

Post, Wendy S. ^{[1
,2
]}

Sears, Cynthia L. ^{[1
,3
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Med, 1550 Orleans St,Suite 1M05, Baltimore, MD 21287 USA

[2] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA

[3] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Mol Microbiol & Immunol, Baltimore, MD USA

[4] Cleveland Clin, Lerner Res Inst, Dept Cellular & Mol Med, Cleveland, OH 44106 USA

[5] Harbor UCLA Med Ctr, Los Angeles Biomed Res Inst, Dept Med, Torrance, CA USA

[6] Northwestern Univ, Dept Med, Chicago, IL 60611 USA

[7] Univ Pittsburgh, Dept Epidemiol, Pittsburgh, PA 15261 USA

来源：

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES | 2016年 / 72卷 / 01期

关键词：

HIV; trimethylamine-N-oxide; coronary artery disease; MULTICENTER AIDS COHORT; CARDIOVASCULAR-DISEASE; MYOCARDIAL-INFARCTION; PROGNOSTIC VALUE; GUT MICROBIOTA; PHOSPHATIDYLCHOLINE; ATHEROSCLEROSIS; METABOLISM; RISK; MORTALITY;

D O I：

10.1097/QAI.0000000000000937

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recent evidence has shown a complex relationship between the gut microbiota, dietary nutrients, and cardiovascular disease (CVD). Trimethylamine-N-oxide (TMAO) production, initiated by the microbiota, has been associated with CVD events. We sought to test if this association exists in HIV-infected persons. After adjusting for aspirin use and CVD risk factors, HIV-infected men were more likely to have coronary stenosis in the second and third TMAO quartiles compared with the first quartile, but did not differ significantly in the fourth quartile. We found an inverted U-shaped association between TMAO levels and the presence of coronary artery stenosis among HIV-infected men.

引用

页码：114 / 118

页数：5

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