Protective effects of bifidobacteria against enteropathogens

被引：24

作者：

Aw, Wanping ^{[1
]}

Fukuda, Shinji ^{[1
,2
,3
,4
]}

机构：

[1] Keio Univ, Inst Adv Biosci, 246-2 Mizukami, Tsuruoka, Yamagata 9970052, Japan

[2] Kanagawa Inst Ind Sci & Technol, Intestinal Microbiota Project, Kawasaki Ku, 3-25-13 Tonomachi, Kawasaki, Kanagawa 2100821, Japan

[3] Univ Tsukuba, Transborder Med Res Ctr, 1-1-1 Tennodai, Tsukuba, Ibaraki 3058575, Japan

[4] Japan Sci & Technol Agcy, PRESTO, 4-1-8 Honcho, Kawaguchi, Saitama 3320012, Japan

来源：

MICROBIAL BIOTECHNOLOGY | 2019年 / 12卷 / 06期

关键词：

ENTEROHEMORRHAGIC ESCHERICHIA-COLI; CHAIN FATTY-ACIDS; GUT MICROBIOTA; METABOLISM; INFECTION; COMMENSAL; NUTRITION; INFANTS;

D O I：

10.1111/1751-7915.13460

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Recent major advances in metagenomics and metabolomics technologies have enabled us to collect more data on the gut microbiome and metabolome to evaluate its influence on host health. In this short opinion article, we have chosen to focus on summarizing the protective mechanisms of bifidobacteria, a highly regarded probiotic, and it's metabolite: acetate; against enteropathogens, specifically in the E. coli O157:H7 mice model. We advocate for using a novel approach metabologenomics, which is an integration of metagenomic and metabolomic information on a systems biology-wide approach to better understand this interplay between gut microbiome and host metabolism.

引用

页码：1097 / 1100

页数：4

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