Salivary IL-8, IL-6 and TNF-α as Potential Diagnostic Biomarkers for Oral Cancer

被引：116

作者：

Sahibzada, Haafsa Arshad ^{[1
]}

Khurshid, Zohaib ^{[2
]}

Sannam Khan, Rabia ^{[3
]}

Naseem, Mustafa ^{[4
]}

Mahmood Siddique, Khalid ^{[5
]}

Mali, Maria ^{[6
]}

Zafar, Muhammad Sohail ^{[7
,8
]}

机构：

[1] Islamabad Dent Hosp, Dept Oral Med, Islamabad 44000, Pakistan

[2] King Faisal Univ, Dept Prosthodont & Implantol, Coll Dent, Al Hasa 31982, Saudi Arabia

[3] Baqai Univ, Dept Oral Pathol, Coll Dent, Super Highway,POB 2407, Karachi 74600, Pakistan

[4] Dar Al Uloom Univ, Dept Prevent Dent Sci, Coll Dent, Riyadh 13314, Saudi Arabia

[5] Islamabad Dent Hosp, Dept Oral Maxillofacial Surg & Oral Med, Islamabad 44000, Pakistan

[6] Fatima Jinnah Dent Coll, Dept Periodontol, Karachi 74000, Pakistan

[7] Al Taibah Univ, Dept Dent Mat, Coll Dent, Madinah Munawwarah 41331, Saudi Arabia

[8] Riphah Int Univ, Dept Dent Mat, Islamic Int Dent Coll, Islamabad 44000, Pakistan

来源：

DIAGNOSTICS | 2017年 / 7卷 / 02期

关键词：

biopsy; saliva; biomarker; interleukin-8; interleukin-6; tumor necrosis factor-alpha (TNF-alpha); cancer and salivaomics; INTERLEUKIN-6; PROTEOMICS; PEPTIDES; CAVITY;

D O I：

10.3390/diagnostics7020021

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Saliva has been useful as a liquid biopsy for the diagnosis of various oral or systemic diseases, and oral squamous cell carcinoma (OSCC) is no exception. While its early detection and prevention is important, salivary cytokines expression, specifically of Interleukin-8 (IL-8), Interleukin-6 (IL-6) and Tumor necrosis factor (TNF-alpha), does contribute to the pathogenesis of cancer and these cytokines serve as potential biomarkers. Their excessive production plays a role in cancer progression and establishment of angiogenesis. However, other inflammatory or immunological conditions may affect the levels of cytokines in saliva. This article reviews the expression of levels of specific cytokines i.e., IL-8, IL-6 and TNF-alpha, their signaling pathways in the development of oral cancer, and how they are essential for the diagnosis of OSCC and updates related to it. Apart from serum, the saliva-based test can be a cost-effective tool in the follow-up and diagnosis of OSCC. Moreover, large-scale investigations are still needed for the validation of salivary cytokines.

引用

页数：10

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