Characterization of ABT-494, a Second Generation Jak1 Selective Inhibitor.

被引:0
|
作者
Graff, Candace [1 ]
Schwartz, Annette [1 ]
Voss, Jeffrey [2 ]
Wishart, Neil [2 ]
Olson, Lisa [1 ]
George, Jonathon [2 ]
Hyland, Deborah [2 ]
Camp, Heidi [3 ]
机构
[1] AbbVie Inc, AbbVie Biores Ctr, Worcester, MA USA
[2] AbbVie Pharmaceut, Worcester, MA USA
[3] Abbvie, Winnetka, IL USA
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
1499
引用
收藏
页码:S659 / S660
页数:2
相关论文
共 50 条
  • [31] Design of a potent and selective dual JAK1/TYK2 inhibitor
    Mammoliti, Oscar
    Menet, Christel
    Cottereaux, Celine
    Blanc, Javier
    De Blieck, Ann
    Coti, Ghjuvanni
    Geney, Raphael
    Oste, Line
    Ostyn, Koen
    Palisse, Adeline
    Quinton, Evelyne
    Schmitt, Benoit
    Borgonovi, Monica
    Parent, Isabelle
    Jagerschmidt, Catherine
    De Vos, Steve
    Vayssiere, Beatrice
    Lopez-Ramos, Miriam
    Shoji, Kenji
    Brys, Reginald
    Amantini, David
    Galien, Rene
    Joannesse, Caroline
    BIOORGANIC & MEDICINAL CHEMISTRY, 2024, 114
  • [32] Dosing Strategy for Itacitinib, a Selective JAK1 Inhibitor, for the Treatment of Ulcerative Colitis
    Barbour, April
    Zhang, Yan
    Punwani, Naresh
    Diamond, Sharon
    Chen, Xuejun
    Yeleswaram, Swamy
    AMERICAN JOURNAL OF GASTROENTEROLOGY, 2019, 114 : S136 - S136
  • [33] A JAK1 Selective Kinase Inhibitor and Tofacitinib Affect Macrophage Activation and Function
    De Vries, L. C. S.
    Duarte, J. M.
    de Krijger, M.
    Welting, O.
    van Harnersveld, P. H. P.
    Van Leeuwen-Hilbers, F. W. M.
    Moerland, P. D.
    Jongejan, A.
    D'Haens, G. R.
    De Jonge, W. J.
    Wildenberg, M. E.
    INFLAMMATORY BOWEL DISEASES, 2019, 25 (04) : 647 - 660
  • [34] Discovery of CYT387: A potent and selective dual inhibitor of JAK1 and JAK2
    Burns, Christopher J.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2010, 240
  • [35] Preclinical characterization of itacitinib (INCB039110), a novel selective inhibitor of JAK1, for the treatment of inflammatory diseases
    Covington, Maryanne
    He, Xin
    Scuron, Monika
    Li, Jun
    Collins, Robert
    Juvekar, Ashish
    Shin, Niu
    Favata, Margaret
    Gallagher, Karen
    Sarah, Sarala
    Xue, Chu-biao
    Peel, Michael
    Burke, Krista
    Oliver, Julian
    Fay, Brittany
    Yao, Wenqing
    Huang, Taisheng
    Scherle, Peggy
    Diamond, Sharon
    Newton, Robert
    Zhang, Yan
    Smith, Paul
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2020, 885
  • [36] JAK1 selective inhibitors for the treatment of spondyloarthropathies
    White, Jonathan P. E.
    Coates, Laura C.
    RHEUMATOLOGY, 2021, 60 : II39 - II44
  • [37] JAK1 selective inhibitors for the treatment of spondyloarthropathies
    White, Jonathan P. E.
    Coates, Laura C.
    RHEUMATOLOGY, 2021, 60 (SUPPL 2) : ii39 - ii44
  • [38] Pharmacokinetic characteristics of golidocitinib, a highly selective JAK1 inhibitor, in healthy adult participants
    Chen, Kan
    Guan, Xiaoduo
    Yang, Zhenfan
    Zhou, Yue
    Liu, Ziyi
    Deng, Xueyuan
    Liu, Donghong
    Hu, Pei
    Chen, Rui
    FRONTIERS IN IMMUNOLOGY, 2023, 14
  • [39] Identification and Biological Evaluation of a Potent and Selective JAK1 Inhibitor for the Treatment of Pulmonary Fibrosis
    Park, Eunsun
    Park, Seolhee
    Lee, Sun Joo
    Jeong, Dayeon
    Jin, Hee
    Moon, Heegyum
    Cha, Boksik
    Kim, Dayea
    Ma, Seonghee
    Seo, Wonhyo
    Han, Seung-Hee
    Lee, Yun-Sil
    Kang, Soosung
    JOURNAL OF MEDICINAL CHEMISTRY, 2023, 66 (23) : 16342 - 16363
  • [40] Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms
    Quintas-Cardama, Alfonso
    Vaddi, Kris
    Liu, Phillip
    Manshouri, Taghi
    Li, Jun
    Scherle, Peggy A.
    Caulder, Eian
    Wen, Xiaoming
    Li, Yanlong
    Waeltz, Paul
    Rupar, Mark
    Burn, Timothy
    Lo, Yvonne
    Kelley, Jennifer
    Covington, Maryanne
    Shepard, Stacey
    Rodgers, James D.
    Haley, Patrick
    Kantarjian, Hagop
    Fridman, Jordan S.
    Verstovsek, Srdan
    BLOOD, 2010, 115 (15) : 3109 - 3117