Characterization of ABT-494, a Second Generation Jak1 Selective Inhibitor.

被引:0
|
作者
Graff, Candace [1 ]
Schwartz, Annette [1 ]
Voss, Jeffrey [2 ]
Wishart, Neil [2 ]
Olson, Lisa [1 ]
George, Jonathon [2 ]
Hyland, Deborah [2 ]
Camp, Heidi [3 ]
机构
[1] AbbVie Inc, AbbVie Biores Ctr, Worcester, MA USA
[2] AbbVie Pharmaceut, Worcester, MA USA
[3] Abbvie, Winnetka, IL USA
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
1499
引用
收藏
页码:S659 / S660
页数:2
相关论文
共 50 条
  • [1] In vitro and in vivo characterization of the JAK1 selectivity of upadacitinib (ABT-494)
    Parmentier J.M.
    Voss J.
    Graff C.
    Schwartz A.
    Argiriadi M.
    Friedman M.
    Camp H.S.
    Padley R.J.
    George J.S.
    Hyland D.
    Rosebraugh M.
    Wishart N.
    Olson L.
    Long A.J.
    BMC Rheumatology, 2 (1)
  • [2] PHARMACOKINETICS, SAFETY AND TOLERABILITY OF THE SELECTIVE JAK1 INHIBITOR, ABT-494, IN HEALTHY VOLUNTEERS AND SUBJECTS WITH RHEUMATOID ARTHRITIS
    Mohamed, M. -E.
    Camp, H.
    Jiang, P.
    Padley, R.
    Asatryan, A.
    Othman, A. A.
    ANNALS OF THE RHEUMATIC DISEASES, 2015, 74 : 258 - 258
  • [3] SAFETY AND EFFICACY OF ABT-494, A NOVEL SELECTIVE JAK1 INHIBITOR, IN PATIENTS WITH ACTIVE RHEUMATOID ARTHRITIS WITH AN INADEQUATE RESPONSE TO METHOTREXATE
    Genovese, M. C.
    Smolen, J. S.
    Weinblatt, M. E.
    Meerwein, S.
    Camp, H. S.
    Wang, L.
    Othman, A. A.
    Khan, N.
    Jungerwirth, S.
    ANNALS OF THE RHEUMATIC DISEASES, 2016, 75 : 141 - 142
  • [4] Pharmacokinetics, Safety and Tolerability of ABT-494, a Novel Selective JAK 1 Inhibitor, in Healthy Volunteers and Subjects with Rheumatoid Arthritis
    Mohamed, Mohamed-Eslam F.
    Camp, Heidi S.
    Jiang, Ping
    Padley, Robert J.
    Asatryan, Armen
    Othman, Ahmed A.
    CLINICAL PHARMACOKINETICS, 2016, 55 (12) : 1547 - 1558
  • [5] Pharmacokinetics, Safety and Tolerability of ABT-494, a Novel Selective JAK 1 Inhibitor, in Healthy Volunteers and Subjects with Rheumatoid Arthritis
    Mohamed-Eslam F. Mohamed
    Heidi S. Camp
    Ping Jiang
    Robert J. Padley
    Armen Asatryan
    Ahmed A. Othman
    Clinical Pharmacokinetics, 2016, 55 : 1547 - 1558
  • [6] SAFETY AND EFFICACY OF ABT-494 (UPADACITINIB), AN ORAL JAK1 INHIBITOR, AS INDUCTION THERAPY IN PATIENTS WITH CROHN'S DISEASE: RESULTS FROM CELEST
    Sandborn, William J.
    Feagan, Brian G.
    Panes, Julian
    D'Haens, Geert R.
    Colombel, Jean Frederic
    Zhou, Qian
    Huang, Bidan
    Enejosa, Jeffrey V.
    Pangan, Aileen L.
    Lacerda, Ana P.
    GASTROENTEROLOGY, 2017, 152 (05) : S1308 - S1309
  • [7] SAFETY AND EFFICACY OF ABT-494, A NOVEL SELECTIVE JAK1 INHIBITOR, IN PATIENTS WITH ACTIVE RHEUMATOID ARTHRITIS AND INADEQUATE RESPONSE OR INTOLERANCE TO ANTI-TNF BIOLOGIC THERAPY
    Kremer, J. M.
    Keystone, E. C.
    Emery, P.
    Camp, H. S.
    Friedman, A.
    Wang, L.
    Othman, A. A.
    Khan, N.
    Jungerwirth, S.
    ANNALS OF THE RHEUMATIC DISEASES, 2016, 75 : 1038 - 1039
  • [8] Safety and Efficacy of ABT-494, a Novel Selective JAK1 Inhibitor, in Patients with Active Rheumatoid Arthritis and Inadequate Response or Intolerance to Anti-TNF Biologic Therapy
    Kremer, Joel M.
    Keystone, Edward C.
    Emery, Paul
    Camp, Heidi S.
    Friedman, Alan
    Wang, Li
    Othman, Ahmed A.
    Khan, Nasser
    Jungerwirth, Steven
    ARTHRITIS & RHEUMATOLOGY, 2015, 67
  • [9] CHANGES IN C-REACTIVE PROTEIN AND LIPID LEVELS IN PATIENTS WITH RHEUMATOID ARTHRITIS TREATED WITH ABT-494, A SELECTIVE JAK-1 INHIBITOR
    Nurmohamed, M.
    Zhang, Y.
    Lin, J.
    Camp, H.
    ANNALS OF THE RHEUMATIC DISEASES, 2017, 76 : 280 - 280
  • [10] Efficacy and Safety of ABT-494, a Selective JAK-1 Inhibitor, in a Phase IIb Study in Patients With Rheumatoid Arthritis and an Inadequate Response to Methotrexate
    Genovese, Mark C.
    Smolen, Josef S.
    Weinblatt, Michael E.
    Burmester, Gerd R.
    Meerwein, Sebastian
    Camp, Heidi S.
    Wang, Li
    Othman, Ahmed A.
    Khan, Nasser
    Pangan, Aileen L.
    Jungerwirth, Steven
    ARTHRITIS & RHEUMATOLOGY, 2016, 68 (12) : 2857 - 2866