Importance of a Liver Biopsy in the Management of Wilson Disease

被引：7

作者：

Oe, Shinji ^{[1
]}

Honma, Yuichi ^{[1
]}

Yabuki, Kei ^{[2
]}

Morino, Kahori ^{[1
]}

Kumamoto, Keiichiro ^{[1
,3
]}

Hayashi, Tsuguru ^{[1
]}

Kusanaga, Masashi ^{[1
]}

Ogino, Noriyoshi ^{[1
]}

Minami, Sota ^{[1
]}

Shibata, Michihiko ^{[1
]}

Abe, Shintaro ^{[1
]}

Harada, Masaru ^{[1
]}

机构：

[1] Univ Occupat & Environm Hlth, Sch Med, Dept Internal Med 3, Kitakyushu, Fukuoka, Japan

[2] Univ Occupat & Environm Hlth, Sch Med, Dept Pathol & Oncol, Kitakyushu, Fukuoka, Japan

[3] Univ Occupat & Environm Hlth, Sch Med, Dept Pathol & Cell Biol, Kitakyushu, Fukuoka, Japan

来源：

INTERNAL MEDICINE | 2020年 / 59卷 / 01期

关键词：

Wilson disease; liver biopsy; hepatic copper content; DIAGNOSIS;

D O I：

10.2169/internalmedicine.3440-19

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 37-year-old Wilson disease patient treated with D-penicillamine visited our hospital for the evaluation of his liver function. Laboratory data showed a low serum copper level and ceruloplasmin. The ratio of urinary copper to urinary creatinine in a spot urinary analysis after 4 days' cessation of D-penicillamine was under 0.1. We concluded that the copper chelation was excessive and changed D-penicillamine to zinc acetate. However, his liver function test results did not normalize. We performed a liver biopsy and discovered a high copper content. The liver dysfunction was improved after resuming chelating therapy. Accurate measurement of the hepatic copper content via a biopsy is important for the adequate management of this disease.

引用

页码：77 / 81

页数：5

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