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Huazhong Univ Sci & Technol, Key Lab Biomed Photon MOE, Wuhan Natl Lab Optoelect,Dept Biomed Engn,Coll Li, Hubei Bioinformat & Mol Imaging Key Lab,Syst Biol, Wuhan 430074, Hubei, Peoples R China Huazhong Univ Sci & Technol, Key Lab Biomed Photon MOE, Wuhan Natl Lab Optoelect,Dept Biomed Engn,Coll Li, Hubei Bioinformat & Mol Imaging Key Lab,Syst Biol, Wuhan 430074, Hubei, Peoples R China