Notch3, another Notch in T cell development

被引：32

作者：

Bellavia, D

Campese, AF

Vacca, A

Gulino, A

Screpanti, I

机构：

[1] Univ Roma Tor Vergata, Dept Expt Med & Pathol, I-00161 Rome, Italy

[2] Univ Roma Tor Vergata, Ist Pasteur, Fondaz Cenci, Bolognetti Fdn, I-00161 Rome, Italy

来源：

SEMINARS IN IMMUNOLOGY | 2003年 / 15卷 / 02期

关键词：

E2A; NF-kappa B; Notch3; pre-TCR; thymus;

D O I：

10.1016/S1044-5323(03)00007-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Different members of the Notch family have been described to play a critical role in T cell lineage commitment and T cell development and functions. Nevertheless, whether they act as redundant molecules, by affecting the same molecular mechanisms, or play distinct roles in T cell differentiation and/or functions is not clear. Altered Notch3 signaling impairs the developmentally regulated interplay between pre-TCR and NF-kappaB signaling and allows the disruption of early thymocyte differentiation and the development of T cell leukemia, thus identifying the crucial role of Notch3 receptor in the coordination of T cell differentiation and growth control. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

收藏

页码：107 / 112

页数：6

相关论文

共 39 条

[1] Constitutive pre-TCR signaling promotes differentiation through Ca2+ mobilization and activation of NF-κB and NFAT [J].

Aifantis, I ;

Gounari, F ;

Scorrano, L ;

Borowski, C ;

von Boehmer, H .

NATURE IMMUNOLOGY, 2001, 2 (05) :403-409

[2] Essential roles for ankyrin repeat and transactivation domains in induction of T-cell leukemia by Notch1 [J].

Aster, JC ;

Xu, LW ;

Karnell, FG ;

Patriub, V ;

Pui, JC ;

Pear, WS .

MOLECULAR AND CELLULAR BIOLOGY, 2000, 20 (20) :7505-7515

[3] E2A deficiency leads to abnormalities in alpha beta T-cell development and to rapid development of T-cell lymphomas [J].

Bain, G ;

Enel, I ;

Maandag, ECR ;

teRiele, HPJ ;

Voland, JR ;

Sharp, LL ;

Chun, J ;

Huey, B ;

Pinkel, D ;

Murre, C .

MOLECULAR AND CELLULAR BIOLOGY, 1997, 17 (08) :4782-4791

[4] Constitutive activation of NF-κB and T-cell leukemia/lymphoma in Notch3 transgenic mice [J].

Bellavia, D ;

Campese, AF ;

Alesse, E ;

Vacca, A ;

Felli, MP ;

Balestri, A ;

Stoppacciaro, A ;

Tiveron, C ;

Tatangelo, L ;

Giovarelli, M ;

Gaetano, C ;

Ruco, L ;

Hoffman, ES ;

Hayday, AC ;

Lendahl, U ;

Frati, L ;

Gulino, A ;

Screpanti, I .

EMBO JOURNAL, 2000, 19 (13) :3337-3348

[5] Combined expression of pTα and Notch3 in T cell leukemia identifies the requirement of preTCR for leukemogenesis [J].

Bellavia, D ;

Campese, AF ;

Checquolo, S ;

Balestri, A ;

Biondi, A ;

Cazzaniga, G ;

Lendahl, U ;

Fehling, HJ ;

Hayday, AC ;

Frati, L ;

von Boehmer, H ;

Gulino, A ;

Screpanti, I .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (06) :3788-3793

[6] TOWARDS AN INTEGRATED VIEW OF THYMOPOIESIS [J].

BOYD, RL ;

HUGO, P .

IMMUNOLOGY TODAY, 1991, 12 (02) :71-+

[7] The v-rel oncogene promotes malignant T-cell leukemia/lymphoma in transgenic mice [J].

Carrasco, D ;

Rizzo, CA ;

Dorfman, K ;

Bravo, R .

EMBO JOURNAL, 1996, 15 (14) :3640-3650

[8] Correlating notch signaling with thymocyte maturation [J].

Deftos, ML ;

He, YW ;

Ojala, EW ;

Bevan, MJ .

IMMUNITY, 1998, 9 (06) :777-786

[9] Notch1 signaling promotes the maturation of CD4 and CD8 SP thymocytes [J].

Deftos, ML ;

Huang, E ;

Ojala, EW ;

Forbush, KA ;

Bevan, MJ .

IMMUNITY, 2000, 13 (01) :73-84

[10] Early thymocyte development is regulated by modulation of E2A protein activity [J].

Engel, I ;

Johns, C ;

Bain, G ;

Rivera, RR ;

Murre, C .

JOURNAL OF EXPERIMENTAL MEDICINE, 2001, 194 (06) :733-745

← 1 2 3 4 →