Confined nanoparticles growth within hollow mesoporous nanoreactors for highly efficient MRI-guided photodynamic therapy

被引：27

作者：

Du, Wenxian ^{[1
,2
]}

Liu, Tianzhi ^{[1
,2
]}

Xue, Fengfeng ^{[1
]}

Chen, Yu ^{[1
]}

Chen, Qian ^{[1
,2
]}

Luo, Yu ^{[3
]}

Cai, Xiaojun ^{[4
]}

Ma, Ming ^{[1
]}

Chen, Hangrong ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China

[2] Univ Chinese Acad Sci, Ctr Mat Sci & Optoelect Engn, Beijing 100049, Peoples R China

[3] Tongji Univ, Sch Chem Sci & Engn, Shanghai 200092, Peoples R China

[4] Shanghai Jiao Tong Univ, Sch Med, Shanghai Peoples Hosp 6, Shanghai 200233, Peoples R China

来源：

CHEMICAL ENGINEERING JOURNAL | 2020年 / 379卷

基金：

中国国家自然科学基金; 上海市自然科学基金;

关键词：

Hollow mesoporous nanoreactors; C18TMS; On/off switching; Photodynamic therapy; MRI; SILICA NANOPARTICLES; OXIDE NANOPARTICLES; CARBON DOTS; THERANOSTICS; HYPOXIA;

D O I：

10.1016/j.cej.2019.122251

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Mesoporous silica nanoparticles (MSNs) have been extensively applied as a promising carrier in biomedical application due to their excellent structure with tunable function. Based on the fact that the surfactant trimethoxyoctadecylsilane (C18TMS) could present different on/off states in different solvents, herein, an intelligent "on/off" switching strategy of site-specific co-loading MnOx and Ce6 into MSNs was proposed for the first time. The multifunctional theranostic nanoplatform, i.e., Ce6/MnOx@HMSNs-PEG (CMHP), shows a sensitive longitudinal relaxation signal to the over-expressed hydrogen peroxide (H2O2) and weak acidic pH in the tumor microenvironment (TME). Furthermore, MnOx component could react with H2O2 in TME to generate O-2, which enable to relieve tumorous hypoxia and afterwards accelerate the generation of singlet oxygen (O-1(2) ) upon laser irradiation when combined with Ce6. Both in vitro and in vivo results confirm that this constructed nanosystem can be applied to MRI-guided sufficient photodynamic therapy (PDT) with reduced side-effects.

引用

页数：9

共 37 条

[1] The present and future role of photodynamic therapy in cancer treatment [J].

Brown, SB ;

Brown, EA ;

Walker, I .

LANCET ONCOLOGY, 2004, 5 (08) :497-508

[2] Biodegradable hollow silica nanospheres containing gold nanoparticle arrays [J].

Cassano, Domenico ;

Martir, Diego Rota ;

Signore, Giovanni ;

Piazza, Vincenzo ;

Voliani, Valerio .

CHEMICAL COMMUNICATIONS, 2015, 51 (49) :9939-9941

[3] Manganese oxide-based multifunctionalized mesoporous silica nanoparticles for pH-responsive MRI, ultrasonography and circumvention of MDR in cancer cells [J].

Chen, Yu ;

Yin, Qi ;

Ji, Xiufeng ;

Zhang, Shengjian ;

Chen, Hangrong ;

Zheng, Yuanyi ;

Sun, Yang ;

Qu, Haiyun ;

Wang, Zheng ;

Li, Yaping ;

Wang, Xia ;

Zhang, Kun ;

Zhang, Linlin ;

Shi, Jianlin .

BIOMATERIALS, 2012, 33 (29) :7126-7137

[4] Multifunctional Mesoporous Composite Nanocapsules for Highly Efficient MRI-Guided High-Intensity Focused Ultrasound Cancer Surgery [J].

Chen, Yu ;

Chen, Hangrong ;

Sun, Yang ;

Zheng, Yuanyi ;

Zeng, Deping ;

Li, Faqi ;

Zhang, Shengjian ;

Wang, Xia ;

Zhang, Kun ;

Ma, Ming ;

He, Qianjun ;

Zhang, Linlin ;

Shi, Jianlin .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2011, 50 (52) :12505-12509

[5] Hollow/Rattle-Type Mesoporous Nanostructures by a Structural Difference-Based Selective Etching Strategy [J].

Chen, Yu ;

Chen, Hangrong ;

Guo, Limin ;

He, Qianjun ;

Chen, Feng ;

Zhou, Jian ;

Feng, Jingwei ;

Shi, Jianlin .

ACS NANO, 2010, 4 (01) :529-539

[6] Multifunctional Nanoparticles: Cost Versus Benefit of Adding Targeting and Imaging Capabilities [J].

Cheng, Zhiliang ;

Al Zaki, Ajlan ;

Hui, James Z. ;

Muzykantov, Vladimir R. ;

Tsourkas, Andrew .

SCIENCE, 2012, 338 (6109) :903-910

[7] Degradability and Clearance of Silicon, Organosilica, Silsesquioxane, Silica Mixed Oxide, and Mesoporous Silica Nanoparticles [J].

Croissant, Jonas G. ;

Fatieiev, Yevhen ;

Khashab, Niveen M. .

ADVANCED MATERIALS, 2017, 29 (09)

[8] Synthesis of Hollow Biomineralized CaCO3-Polydopamine Nanoparticles for Multimodal Imaging-Guided Cancer Photodynamic Therapy with Reduced Skin Photosensitivity [J].

Dong, Ziliang ;

Feng, Liangzhu ;

Hao, Yu ;

Chen, Muchao ;

Gao, Min ;

Chao, Yu ;

Zhao, He ;

Zhu, Wenwen ;

Liu, Jingjing ;

Liang, Chao ;

Zhang, Qiao ;

Liu, Zhaung .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2018, 140 (06) :2165-2178

[9] Recent advances in functional nanomaterials for light-triggered cancer therapy [J].

Gai, Shili ;

Yang, Guixin ;

Yang, Piaoping ;

He, Fei ;

Lin, Jun ;

Jin, Dayong ;

Xing, Bengang .

NANO TODAY, 2018, 19 :146-187

[10] A graphene quantum dot photodynamic therapy agent with high singlet oxygen generation [J].

Ge, Jiechao ;

Lan, Minhuan ;

Zhou, Bingjiang ;

Liu, Weimin ;

Guo, Liang ;

Wang, Hui ;

Jia, Qingyan ;

Niu, Guangle ;

Huang, Xing ;

Zhou, Hangyue ;

Meng, Xiangmin ;

Wang, Pengfei ;

Lee, Chun-Sing ;

Zhang, Wenjun ;

Han, Xiaodong .

NATURE COMMUNICATIONS, 2014, 5

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