Metabolic reprogramming of immune cells: Shaping the tumor microenvironment in hepatocellular carcinoma

被引：26

作者：

Xia, Yujia ^{[1
,2
]}

Brown, Zachary J. ^{[1
]}

Huang, Hai ^{[1
]}

Tsung, Allan ^{[1
]}

机构：

[1] Ohio State Univ, Dept Surg, Div Surg Oncol, Wexner Med Ctr, Columbus, OH 43210 USA

[2] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Gastroenterol, Wuhan, Hubei, Peoples R China

来源：

CANCER MEDICINE | 2021年 / 10卷 / 18期

基金：

中国国家自然科学基金;

关键词：

hepatocellular carcinoma; immune cells; metabolic reprogramming; tumor immunology; tumor microenvironment; FATTY-ACID OXIDATION; MACROPHAGE ACTIVATION; ENERGY-METABOLISM; M2; MACROPHAGES; REGULATORY T; CANCER; CHECKPOINT; EFFECTOR; REQUIREMENTS; POLARIZATION;

D O I：

10.1002/cam4.4177

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Hepatocellular carcinoma (HCC) is a typical inflammation-induced cancer and displays a complex interaction between the tumor microenvironment and tumor development. Immune cells in the HCC microenvironment play both pro- and anti-tumoral roles in HCC progression. An increasing number of findings indicate that metabolic reprogramming is essential for immune cell differentiation and function. In this review, we discuss the metabolic changes of different immune cells and correlate these findings to HCC progression.

引用

页码：6374 / 6383

页数：10

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