Metabolic reprogramming of immune cells: Shaping the tumor microenvironment in hepatocellular carcinoma

被引：26

作者：

Xia, Yujia ^{[1
,2
]}

Brown, Zachary J. ^{[1
]}

Huang, Hai ^{[1
]}

Tsung, Allan ^{[1
]}

机构：

[1] Ohio State Univ, Dept Surg, Div Surg Oncol, Wexner Med Ctr, Columbus, OH 43210 USA

[2] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Gastroenterol, Wuhan, Hubei, Peoples R China

来源：

CANCER MEDICINE | 2021年 / 10卷 / 18期

基金：

中国国家自然科学基金;

关键词：

hepatocellular carcinoma; immune cells; metabolic reprogramming; tumor immunology; tumor microenvironment; FATTY-ACID OXIDATION; MACROPHAGE ACTIVATION; ENERGY-METABOLISM; M2; MACROPHAGES; REGULATORY T; CANCER; CHECKPOINT; EFFECTOR; REQUIREMENTS; POLARIZATION;

D O I：

10.1002/cam4.4177

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Hepatocellular carcinoma (HCC) is a typical inflammation-induced cancer and displays a complex interaction between the tumor microenvironment and tumor development. Immune cells in the HCC microenvironment play both pro- and anti-tumoral roles in HCC progression. An increasing number of findings indicate that metabolic reprogramming is essential for immune cell differentiation and function. In this review, we discuss the metabolic changes of different immune cells and correlate these findings to HCC progression.

引用

页码：6374 / 6383

页数：10

共 121 条

[1] Type I IFNs induce anti-tumor polarization of tumor associated neutrophils in mice and human [J].

Andzinski, Lisa ;

Kasnitz, Nadine ;

Stahnke, Stephanie ;

Wu, Ching-Fang ;

Gereke, Marcus ;

von Koeckritz-Blickwede, Maren ;

Schilling, Bastian ;

Brandau, Sven ;

Weiss, Siegfried ;

Jablonska, Jadwiga .

INTERNATIONAL JOURNAL OF CANCER, 2016, 138 (08) :1982-1993

[2] mTOR regulates memory CD8 T-cell differentiation [J].

Araki, Koichi ;

Turner, Alexandra P. ;

Shaffer, Virginia Oliva ;

Gangappa, Shivaprakash ;

Keller, Susanne A. ;

Bachmann, Martin F. ;

Larsen, Christian P. ;

Ahmed, Rafi .

NATURE, 2009, 460 (7251) :108-U124

[3] A Metabolic Shift toward Pentose Phosphate Pathway Is Necessary for Amyloid Fibril-and Phorbol 12-Myristate 13-Acetate-induced Neutrophil Extracellular Trap (NET) Formation [J].

Azevedo, Estefania P. ;

Rochael, Natalia C. ;

Guimaraes-Costa, Anderson B. ;

de Souza-Vieira, Thiago S. ;

Ganilho, Juliana ;

Saraiva, Elvira M. ;

Palhano, Fernando L. ;

Foguel, Debora .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2015, 290 (36) :22174-22183

[4] Metabolic-epigenetic crosstalk in macrophage activation [J].

Baardman, Jeroen ;

Licht, Iris ;

de Winther, Menno P. J. ;

Van den Bossche, Jan .

EPIGENOMICS, 2015, 7 (07) :1155-1164

[5] The tumor microenvironment at a glance [J].

Balkwill, Frances R. ;

Capasso, Melania ;

Hagemann, Thorsten .

JOURNAL OF CELL SCIENCE, 2012, 125 (23) :5591-5596

[6] De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells [J].

Berod, Luciana ;

Friedrich, Christin ;

Nandan, Amrita ;

Freitag, Jenny ;

Hagemann, Stefanie ;

Harmrolfs, Kirsten ;

Sandouk, Aline ;

Hesse, Christina ;

Castro, Carla N. ;

Baehres, Heike ;

Tschirner, Sarah K. ;

Gorinski, Nataliya ;

Gohmert, Melanie ;

Mayer, Christian T. ;

Huehn, Jochen ;

Ponimaskin, Evgeni ;

Abraham, Wolf-Rainer ;

Mueller, Rolf ;

Lochner, Matthias ;

Sparwasser, Tim .

NATURE MEDICINE, 2014, 20 (11) :1327-1333

[7]

Bihl F., 1950, J IMMUNOL, V2010, P2174

[8] Metabolic Reprogramming of Immune Cells in Cancer Progression [J].

Biswas, Subhra K. .

IMMUNITY, 2015, 43 (03) :435-449

[9] Orchestration of Metabolism by Macrophages [J].

Biswas, Subhra K. ;

Mantovani, Alberto .

CELL METABOLISM, 2012, 15 (04) :432-437

[10] ENERGY-METABOLISM OF HUMAN-NEUTROPHILS DURING PHAGOCYTOSIS [J].

BORREGAARD, N ;

HERLIN, T .

JOURNAL OF CLINICAL INVESTIGATION, 1982, 70 (03) :550-557

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