Tumoricidal activity of lauryl gallate towards chemically induced skin tumours in mice

被引：23

作者：

Ortega, E ^{[1
]}

Sadabal, MC ^{[1
]}

Ortiz, AI ^{[1
]}

Cespon, C ^{[1
]}

Rocamora, A ^{[1
]}

Escolano, JM ^{[1
]}

Roy, G ^{[1
]}

Villar, LM ^{[1
]}

Gonzalez-Porque, P ^{[1
]}

机构：

[1] Hosp Ramon & Cajal, Serv Inmunol, E-28034 Madrid, Spain

来源：

BRITISH JOURNAL OF CANCER | 2003年 / 88卷 / 06期

关键词：

lauryl gallate; antioxidants; protein tyrosine kinase inhibitors; antitumoral agents; food additives;

D O I：

10.1038/sj.bjc.6600805

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Lauryl gallate (antioxidant food additive E-312) prevents the formation of dimethylbenzanthracene-induced skin tumours in mice, and kills, selectively, tumoral cells on established tumours. This results in total remission, after topical application of the compound on the tumoral mass, without affecting the surrounding tissue, (C) 2003 Cancer Research UK.

引用

页码：940 / 943

页数：4

共 17 条

[1] Pharmacodynamic studies of the epidermal growth factor receptor inhibitor ZD1839 in skin from cancer patients: Histopathologic and molecular consequences of receptor inhibition [J].

Albanell, J ;

Rojo, F ;

Averbuch, S ;

Feyereislova, A ;

Mascaro, JM ;

Herbst, R ;

LoRusso, P ;

Rischin, D ;

Sauleda, S ;

Gee, J ;

Nicholson, RI ;

Baselga, J .

JOURNAL OF CLINICAL ONCOLOGY, 2002, 20 (01) :110-124

[2] Oncogenic kinase signalling [J].

Blume-Jensen, P ;

Hunter, T .

NATURE, 2001, 411 (6835) :355-365

[3] Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization [J].

Bossy-Wetzel, E ;

Newmeyer, DD ;

Green, DR .

EMBO JOURNAL, 1998, 17 (01) :37-49

[4]

BURGER AM, 1995, CANCER RES, V55, P2794

[5]

Kolibaba K, 1997, BIOCHIM BIOPHYS ACTA, V1333, P217

[6] INHIBITION OF HUMAN SPLEEN PROTEIN-TYROSINE KINASES BY PHENOLIC-COMPOUNDS [J].

LAZARO, I ;

PALACIOS, C ;

GONZALES, M ;

GONZALEZPORQUE, P .

ANALYTICAL BIOCHEMISTRY, 1995, 225 (01) :180-183

[7] Tyrosine kinase inhibitors in preclinical development [J].

Levitt, ML ;

Koty, PP .

INVESTIGATIONAL NEW DRUGS, 1999, 17 (03) :213-226

[8]

OTANI H, 1993, J BIOL CHEM, V268, P22733

[9] Lauryl gallate inhibits the activity of protein tyrosine kinase c-Src purified from human platelets [J].

Palacios, C ;

Cespón, C ;

De la Vega, CM ;

Roy, G ;

Serrano, A ;

Salinas, M ;

González-Porqué, P .

JOURNAL OF ENZYME INHIBITION, 2001, 16 (06) :527-533

[10] Tyrosine kinase receptor-activated signal transduction pathways which lead to oncogenesis [J].

Porter, AC ;

Vaillancourt, RR .

ONCOGENE, 1998, 17 (11) :1343-1352

← 1 2 →