Methicillin-resistant Staphylococcus aureus producing Panton-Valentine leukocidin as a cause of acute osteomyelitis in children

被引：26
作者：
Sdougkos, G.
Chini, V.
Papanastasiou, D. A.
Christodoulou, G.
Tagaris, G.
Dimitracopoulos, G.
Spiliopoulou, I. [1 ]
机构：
[1] Univ Patras, Dept Microbiol, Sch Med, Patras 26500, Greece
[2] Univ Patras, Dept Paediat, Sch Med, Patras 26500, Greece
[3] Karamandane Childrens Hosp, Dept Orthopaed, Patras, Greece
来源：
CLINICAL MICROBIOLOGY AND INFECTION | 2007年 / 13卷 / 06期
关键词：
acute osteomyelitis; children; methicillin-resistant Staphylococcus aureus; Panton-Valentine leukocidin; Staphylococcus aureus;
D O I：
10.1111/j.1469-0691.2007.01713.x
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Staphylococcus aureus was identified as the cause of acute childhood osteomyelitis in 19 patients. A single clone of community-acquired methicillin-resistant S. aureus (MRSA) carrying the type IV mecA staphylococcal cassette chromosome and the Panton-Valentine leukocidin (PVL) genes was isolated from five patients. Among the remaining 14 patients, two methicillin-sensitive S. aureus (MSSA) isolates were PVL-positive. The maximal erythrocyte sedimentation rate and C-reactive protein values, and the time required for normalisation, were significantly different in patients with PVL-positive strains (MRSA and MSSA), suggesting that the production of PVL is an important factor that contributes to the course of the disease.
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收藏
页码：651 / 654
页数：5
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