Structure elucidation of new oleanane-type glycosides from three species of Acanthophyllum

被引：13

作者：

Timite, Gaoussou ^{[1
]}

Mitaine-Offer, Anne-Claire ^{[1
]}

Miyamoto, Tomofumi ^{[2
]}

Ramezani, Mohammad ^{[3
]}

Rustaiyan, Abdolhossein ^{[4
]}

Mirjolet, Jean-Francois ^{[5
]}

Duchamp, Olivier ^{[5
]}

Lacaille-Dubois, Marie-Aleth ^{[1
]}

机构：

[1] Univ Bourgogne, Lab Pharmacognosie, UMIB, Fac Pharm,UPRES EA 3660, F-21079 Dijon, France

[2] Kyushu Univ, Grad Sch Pharmaceut Sci, Fukuoka 8128582, Japan

[3] Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacognosy & Biotechnol, Mashhad, Iran

[4] Shahid Beheshty Univ, Dept Chem, Tehran, Iran

[5] Oncodesign, F-21076 Dijon, France

来源：

MAGNETIC RESONANCE IN CHEMISTRY | 2010年 / 48卷 / 05期

关键词：

NMR; (1)H; (13)C; 2D NMR; triterpene saponins; gypsogenic acid; Caryophyllaceae; Acanthophyllum; TRITERPENE SAPONINS; SQUARROSUM;

D O I：

10.1002/mrc.2577

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

From the roots of three species of Acanthophyllum (Caryophyllaceae), two new gypsogenic acid glycosides, 1 and 2, were isolated, 1 from A. sordidum and A. lilacinum, 2 from A. elatius and A. lilacinum, together with three known saponins, glandulosides B and C, and SAPO50. The structures of 1 and 2 were established mainly by 2D NMR techniques as 23-O-beta-D-galactopyranosylgypsogenic acid-28-O-beta-D-glucopyranosyl-(1 -> 3)-[beta-D-glucopyranosyl-(1 -> 6)]-beta-D-galactopyranoside (1) and gypsogenic acid-28-O-beta-D-glucopyranosyl-(1 -> 3)-[beta-D-glucopyranosyl-(1 -> 6)]-beta-D-galactopyranoside (2). The cytotoxicity of several of these saponins was evaluated against two human colon cancer cell lines (HT-29 and HCT 116). Copyright (C) 2010 John Wiley & Sons, Ltd.

引用

页码：370 / 374

页数：5

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