A Simple "Green" Synthesis of Novel Bis(3-aryl-1,8-naphthyridin-2-yl)sulfanes and 2-(Methylthio)-3-aryl-1,8-naphthyridines under Microwave Irradiation and Conventional Conditions

被引：1
作者：
Ravi, D. [1 ]
Ashok, K. [1 ]
Rambabu, S. [1 ]
Sakram, B. [1 ]
Shyam, P. [2 ]
机构：
[1] Osmania Univ, Dept Chem, Hyderabad 500007, Telangana, India
[2] Natl Inst Nutr, Biomed Informat Ctr, Hyderabad 500007, Telangana, India
来源：
RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2018年 / 88卷 / 06期
关键词：
1,8-naphthyridines; anti-microbial activity; methanol; microwave Irradiation; molecular docking;
D O I：
10.1134/S1070363218060312
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An eco-friendly and highly efficient synthesis of substituted bis(3-aryl-1,8-naphthyridin-2-yl)-sulfanes and 2-(methylthio)-3-aryl-1,8-naphthyridines under microwave and conventional conditions. The products are obtained with high yields and purity within short reaction time. The synthesized derivatives are screened for anti-microbial activity against bacteria and fungi. Molecular docking of the synthesized compounds with DNA Gyrase is studied.
引用
收藏
页码：1232 / 1237
页数：6
相关论文
共 11 条
[1]   Synthesis and evaluation of antihypertensive activity of 1,8-naphthyridine derivatives. Part X [J].
Badawneh, M ;
Ferrarini, PL ;
Calderone, V ;
Manera, C ;
Martinotti, E ;
Mori, C ;
Saccomanni, G ;
Testai, L .
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2001, 36 (11-12) :925-934
[2]   New and more potent antifungal disulfides [J].
Baerlocher, FJ ;
Baerlocher, MO ;
Langler, RF ;
MacQuarrie, SL ;
Marchand, ME .
AUSTRALIAN JOURNAL OF CHEMISTRY, 2000, 53 (01) :1-5
[3]   Type IIA topoisomerase inhibition by a new class of antibacterial agents [J].
Bax, Benjamin D. ;
Chan, Pan F. ;
Eggleston, Drake S. ;
Fosberry, Andrew ;
Gentry, Daniel R. ;
Gorrec, Fabrice ;
Giordano, Ilaria ;
Hann, Michael M. ;
Hennessy, Alan ;
Hibbs, Martin ;
Huang, Jianzhong ;
Jones, Emma ;
Jones, Jo ;
Brown, Kristin Koretke ;
Lewis, Ceri J. ;
May, Earl W. ;
Saunders, Martin R. ;
Singh, Onkar ;
Spitzfaden, Claus E. ;
Shen, Carol ;
Shillings, Anthony ;
Theobald, Andrew J. ;
Wohlkonig, Alexandre ;
Pearson, Neil D. ;
Gwynn, Michael N. .
NATURE, 2010, 466 (7309) :935-U51
[4]   PYRIDONECARBOXYLIC ACIDS AS ANTIBACTERIAL AGENTS .4. SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF 7-(3-AMINO-1-PYRROLIDINYL)-1-ETHYL-6-FLUORO-1,4-DIHYDRO-4-OXO-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID AND ITS ANALOGS [J].
EGAWA, H ;
MIYAMOTO, T ;
MINAMIDA, A ;
NISHIMURA, Y ;
OKADA, H ;
UNO, H ;
MATSUMOTO, J .
JOURNAL OF MEDICINAL CHEMISTRY, 1984, 27 (12) :1543-1548
[5]   MOLECULAR RECOGNITION OF RECEPTOR-SITES USING A GENETIC ALGORITHM WITH A DESCRIPTION OF DESOLVATION [J].
JONES, G ;
WILLETT, P ;
GLEN, RC .
JOURNAL OF MOLECULAR BIOLOGY, 1995, 245 (01) :43-53
[6]  
Mogilaiah K, 2005, J CHEM RES-S, P516
[7]   An Exceedingly Mild, Green Synthesis of Substituted N-3-diaryl-1,8-naphthyridin-2-amine Derivatives and Their Antimicrobial Activity [J].
Ravi, Dharavath ;
Rambabu, Sirgamalla ;
Ashok, Kommakula ;
Madhu, Palithapu ;
Sakram, Boda .
JOURNAL OF HETEROCYCLIC CHEMISTRY, 2018, 55 (04) :957-963
[8]   1,8-naphthyridines IV.: 9-substituted N,N-dialkyl-5-(alkylamino or cycloalkylamino) [1,2,4]triazolo[4,3-a][1,8]naphthyridine-6-carboxamides, new compounds with anti-aggressive and potent anti-inflammatory activities [J].
Roma, G ;
Di Braccio, M ;
Grossi, G ;
Mattioli, F ;
Ghia, M .
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2000, 35 (11) :1021-1035
[9]   Microwave assisted aqueous phase synthesis of benzothiazoles and benzimidazoles in the presence of Ag2O [J].
Sakram, B. ;
Rambabu, S. ;
Ashok, K. ;
Sonyanaik, B. ;
Ravi, D. .
RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2016, 86 (12) :2737-2743
[10]   Eco-friendly synthesis of 1,8-naphthyridine 5-aryl-1,3,4-oxadiazole derivatives under solvent-free solid-state conditions and their antimicrobial activity [J].
Sakram, B. ;
Sonyanaik, B. ;
Ashok, K. ;
Rambabu, S. ;
Ravi, D. ;
Kurumanna, A. ;
Shyam, P. .
RESEARCH ON CHEMICAL INTERMEDIATES, 2017, 43 (03) :1881-1892
12