Aspochalazine A, a novel polycyclic aspochalasin from the fungus Aspergillus sp Z4

被引：15

作者：

Li, Xinyang ^{[1
]}

Zhao, Zhanhai ^{[1
]}

Ding, Wanjing ^{[1
]}

Ye, Bin ^{[1
]}

Wang, Pinmei ^{[1
]}

Xu, Jinzhong ^{[1
]}

机构：

[1] Zhejiang Univ, Inst Marine Biol, Ocean Coll, Zhoushan 316021, Peoples R China

来源：

TETRAHEDRON LETTERS | 2017年 / 58卷 / 25期

基金：

中国国家自然科学基金;

关键词：

Aspochalasin; Gut fungi; Azabicyclo; Cytotoxicity; CYTOCHALASANS; BIOSYNTHESIS;

D O I：

10.1016/j.tetlet.2017.04.071

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel polycyclic aspochalasin, aspochalazine A (1), was isolated along with three related known compounds 2-4 from the culture broth of Aspergillus sp., which was found in the gut of a marine isopod Ligia oceanica. The structures were determined on the basis of ESI-MS, NMR spectrum data and single-crystal X-ray diffraction. This is the first report about aspochalasin derivative with an azabicyclo. Cytotoxicity against the prostate cancer PC3 cell line was assayed by MTT method. Aspochalazine A showed weak activity. A plausible biosynthetic pathway for aspochalazine A was proposed. (C) 2017 Published by Elsevier Ltd.

引用

页码：2405 / 2408

页数：4

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