Comparison of the therapeutic effect and impact of surgery following radiotherapy and chemotherapy following surgery for patients with cervical cancer

被引：0

作者：

You, Dong ^{[1
]}

Wang, Dawei ^{[1
]}

Liu, Tianfeng ^{[2
]}

机构：

[1] Yantai Yuhuangding Hosp, Dept Radiotherapy, Yantai, Shandong, Peoples R China

[2] Linyi Peoples Hosp, Dept Gynecol, 27 Eastern Sect Jiefang Rd, Linyi 276000, Shandong, Peoples R China

来源：

INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE | 2018年 / 11卷 / 05期

关键词：

Cervical cancer; chemotherapy; radiotherapy; surgical treatment; survival rate; HUMAN-PAPILLOMAVIRUS; RADICAL HYSTERECTOMY; HPV; BRACHYTHERAPY; CARBOPLATIN; PACLITAXEL;

D O I：

暂无

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Objective: To compare the therapeutic effect and impact of surgery following radiotherapy and chemotherapy following surgery for patients with cervical cancer. Methods: A total of 329 cervical cancer patients admitted to Yantai Yuhuangding Hospital from May 2008 to December 2014 in the Gynecology and Oncology department were selected as the research objects. Retrospective analysis was carried out and according to different treatment methods, the patients were divided into a surgery-first group (surgery before radiotherapy) of 164 cases, and a chemotherapy-first group (chemotherapy before surgery) of 165 cases. The curative effect, postoperative adverse reactions, complications, and lymph node metastasis were compared between the two groups. All patients were followed up for 3 years, and the survival rate and quality of life in these 3 years were recorded. Results: The total effective rate of the chemotherapy-first group (97.0%) was significantly higher than that of the surgery-first group (89.0%, P=0.019). In regard to total postoperative adverse reactions, the chemotherapy-first group also surpassed the surgery-first group (P<0.001). In terms of survival rates, the 1-, 2- and 3-year survival rate of the chemotherapy-first group were 99.4%, 97.0%, 91.5 respectively, whereas those of the surgery-first group were 97.0%, 89.0%, 75.0% respectively. Compared with the 3 years total survival rate of the two groups, the chemotherapy-first group was significantly superior to the surgery-first group (P=0.048). The average score of quality of life in the chemotherapy- first group was (84.07 +/- 7.69), which was significantly higher than that in the surgery-first group (70.12 +/- 9.59), P<0.001. Conclusion: In treatment of cervical cancer, chemotherapy following surgery achieves better therapeutic effect than the surgery following radiotherapy, which greatly improves the survival rate and quality of life of patients. It is worth promoting in clinical practice.

引用

页码：4998 / 5004

页数：7

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