Biotransformation of 17-alkyl steroids in the equine: high-performance liquid chromatography mass spectrometric and gas chromatography mass spectrometric analysis of fluoxymesterone metabolites in urine samples

被引：19

作者：

Stanley, SMR ^{[1
]}

Kent, S ^{[1
]}

Rodgers, JP ^{[1
]}

机构：

[1] Jockey Club So Africa, Johannesburg, Gauteng, South Africa

来源：

JOURNAL OF CHROMATOGRAPHY B | 1997年 / 704卷 / 1-2期

关键词：

steroids; fluoxymesterone;

D O I：

10.1016/S0378-4347(97)00440-4

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

In this study the equine metabolism of fluoxymesterone (9 alpha-fluoro-11 beta-17 beta-dihydroxy-17 alpha-methylandrost-4-ene-3-one) given orally has been investigated. The parent material was not detected, but two major 16-hydroxy metabolites which corresponded to a mono- and a di-hydroxylation product were evident. One of the hydroxylation positions was identified as C-16. Phase II metabolism in the form of glucuronide formation was also common. These steroids will provide target compounds for confirming abuse of this drug in the horse. (C) 1997 Elsevier Science B.V.

引用

页码：119 / 128

页数：10

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