Synthesis and antibacterial activity of some aryloxy/thioaryloxy oxazolidinone derivatives

被引：18
|
作者：
Arora, V
Salunkhe, MM
Sinha, N
Sinha, RK
Jain, S
机构：
[1] New Chem Ent Res, Div Med Chem, Pune 411042, Maharashtra, India
[2] New Chem Ent Res, Div Microbiol, Pune 411042, Maharashtra, India
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 18期
关键词：
antibacterial; oxazolidinone; aryloxy/thioaryloxy derivatives; resistant bacteria;
D O I：
10.1016/j.bmcl.2004.06.096
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of aryloxy/thioaryloxy oxazolidinone derivatives has been synthesized and tested for in vitro antibacterial activity by MIC determination against a panel of susceptible and resistant Gram-positive and Gram-negative microorganisms, some of which are resistant to methicillin and vancomycin. Compounds 12a, 12b, 14a, and 14b from this series were found to be equipotent or more potent than linezolid in vitro. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4647 / 4650
页数：4
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