Potential antioxidant activity of Morita-Baylis-Hillman adducts

被引：27

作者：

Elleuch, Haitham ^{[1
]}

Mihoubi, Wafa ^{[2
]}

Mihoubi, Mohamed ^{[3
]}

Ketata, Emna ^{[2
]}

Gargouri, Ali ^{[2
]}

Rezgui, Farhat ^{[1
]}

机构：

[1] Univ Tunis El Manar, Fac Sci Tunis, Lab Chim Organ Struct LR99ES14, Campus Univ, Tunis 2092, Tunisia

[2] Univ Sfax, Ctr Biotechnol Sfax, Lab Biotechnol Mol Eucaryotes, Sfax, Tunisia

[3] Fac Sci Sfax, Lab Chim Subst Nat UR11 ES74, BP 1171, Sfax 3000, Tunisia

来源：

BIOORGANIC CHEMISTRY | 2018年 / 78卷

关键词：

DPPH; Phosphonates; Hydrazones; Morita-Baylis-Hillman adducts; GLUTATHIONE;

D O I：

10.1016/j.bioorg.2018.03.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The wide variety of potent biological activities of Morita-Baylis-Hillman adducts (MBH) encouraged us to synthesize new series of products belonging to this class of compounds, possessing different functionalities and exhibiting potential antioxidant activity. As part of our on-going program on targeting molecules with antioxidant activity, we describe herein different DPPH (2,2-diphenyl-1-picrylhydrazyl) scavenging activities of MBH alcohols and their derivatives including acetates, phosphonates and hydrazonophosphonates. The obtained results showed that the strongest DPPH radical scavenging activity was observed in the case of hydrazonophosphonates in comparison to the other MBH derivatives. (C) 2018 Elsevier Inc. All rights reserved.

引用

页码：24 / 28

页数：5

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