Hypoxia inducible factors in liver disease and hepatocellular carcinoma: Current understanding and future directions

被引：159

作者：

Wilson, Garrick K. ^{[1
]}

Tennant, Daniel A. ^{[2
]}

McKeating, Jane A. ^{[1
,3
]}

机构：

[1] Univ Birmingham, Ctr Human Virol, Viral Hepatitis Res Grp, Birmingham B15 2TT, W Midlands, England

[2] Univ Birmingham, Sch Canc Sci, Birmingham B15 2TT, W Midlands, England

[3] Univ Birmingham, NIHR Liver Biomed Res Unit, Birmingham B15 2TT, W Midlands, England

来源：

JOURNAL OF HEPATOLOGY | 2014年 / 61卷 / 06期

关键词：

Hypoxia; Viral hepatitis; Inflammation; HIF; Liver; ENDOTHELIAL GROWTH-FACTOR; VIRUS-X PROTEIN; EPITHELIAL-MESENCHYMAL TRANSITION; MITOCHONDRIAL COMPLEX-III; REGULATORY T-CELLS; TISSUE IN-VIVO; HEPATITIS-C; TRANSCRIPTION FACTOR; RAT-LIVER; LYSOPHOSPHATIDIC ACID;

D O I：

10.1016/j.jhep.2014.08.025

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Hypoxia inducible transcription factors (HIFs) activate diverse pathways that regulate cellular metabolism, angiogenesis, proliferation, and migration, enabling a cell to respond to a low oxygen or hypoxic environment. HIFs are regulated by oxygen-dependent and independent signals including: mitochondrial dysfunction, reactive oxygen species, endoplasmic reticular stress, and viral infection. HIFs have been reported to play a role in the pathogenesis of liver disease of diverse aetiologies. This review explores the impact of HIFs on hepatocellular biology and inflammatory responses, highlighting the therapeutic potential of targeting HIFs for an array of liver pathologies. (C) 2014 Published by Elsevier B.V. on behalf of the European Association for the Study of the Liver.

引用

页码：1397 / 1406

页数：10

共 137 条

[1] Macrophage Oxygen Sensing Modulates Antigen Presentation and Phagocytic Functions Involving IFN-γ Production through the HIF-1α Transcription Factor [J].

Acosta-Iborra, Barbara ;

Elorza, Ainara ;

Olazabal, Isabel M. ;

Martin-Cofreces, Noa B. ;

Martin-Puig, Silvia ;

Miro, Marta ;

Calzada, Maria J. ;

Aragones, Julian ;

Sanehez-Madrid, Francisco ;

Landazuri, Manuel O. .

JOURNAL OF IMMUNOLOGY, 2009, 182 (05) :3155-3164

[2] Oxygen-independent Regulation of HIF-1: Novel Involvement of PI3K/AKT/mTOR Pathway in Cancer [J].

Agani, Faton ;

Jiang, Bing-Hua .

CURRENT CANCER DRUG TARGETS, 2013, 13 (03) :245-251

[3] Adenosine-dependent activation of hypoxia-inducible factor-1 induces late preconditioning in liver cells [J].

Alchera, Elisa ;

Tacchini, Lorenza ;

Imarisio, Chiara ;

Dal Ponte, Caterina ;

De Ponti, Cristina ;

Gammella, Elena ;

Cairo, Gaetano ;

Albano, Emanuele ;

Carini, Rita .

HEPATOLOGY, 2008, 48 (01) :230-239

[4] Chronic enteral ethanol treatment causes hypoxia in rat liver tissue in vivo [J].

Arteel, GE ;

Iimuro, Y ;

Yin, M ;

Raleigh, JA ;

Thurman, RG .

HEPATOLOGY, 1997, 25 (04) :920-926

[5] The importance of cycling of blood alcohol levels in the pathogenesis of experimental alcoholic liver disease in rats [J].

Bardag-Gorce, F ;

French, BA ;

Li, J ;

Riley, NE ;

Yuan, QX ;

Valinluck, V ;

Fu, P ;

Ingelman-Sundberg, M ;

Yoon, S ;

French, SW .

GASTROENTEROLOGY, 2002, 123 (01) :325-335

[6] Liver fibrosis [J].

Bataller, R ;

Brenner, DA .

JOURNAL OF CLINICAL INVESTIGATION, 2005, 115 (02) :209-218

[7] Hypoxia controls CD4+CD25+ regulatory T-cell homeostasis via hypoxia-inducible factor-1α [J].

Ben-Shoshan, Jeremy ;

Maysel-Auslender, Sophia ;

Mor, Adi ;

Keren, Gad ;

George, Jacob .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2008, 38 (09) :2412-2418

[8] HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1α in normoxia [J].

Berra, E ;

Benizri, E ;

Ginouvès, A ;

Volmat, V ;

Roux, D ;

Pouysségur, J .

EMBO JOURNAL, 2003, 22 (16) :4082-4090

[9] HIF-1α influences myeloid cell antigen presentation and response to subcutaneous OVA vaccination [J].

Bhandari, Tamara ;

Olson, Joshua ;

Johnson, Randall S. ;

Nizet, Victor .

JOURNAL OF MOLECULAR MEDICINE-JMM, 2013, 91 (10) :1199-1205

[10] Bone marrow injection stimulates hepatic ductular reactions in the absence of injury via macrophage-mediated TWEAK signaling [J].

Bird, Thomas G. ;

Lu, Wei-Yu ;

Boulter, Luke ;

Gordon-Keylock, Sabrina ;

Ridgway, Rachel A. ;

Williams, Michael J. ;

Taube, Jessica ;

Thomas, James A. ;

Wojtacha, Davina ;

Gambardella, Adriana ;

Sansom, Owen J. ;

Iredale, John P. ;

Forbes, Stuart J. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (16) :6542-6547

← 1 2 3 4 5 6 7 8 9 10 →