Nicotinamide for skin cancer chemoprevention

被引：25

作者：

Damian, Diona L. ^{[1
,2
]}

机构：

[1] Univ Sydney, Royal Prince Alfred Hosp, Cent Clin Sch, Discipline Dermatol, Sydney, NSW, Australia

[2] Melanoma Inst Australia, Sydney, NSW, Australia

来源：

AUSTRALASIAN JOURNAL OF DERMATOLOGY | 2017年 / 58卷 / 03期

基金：

英国医学研究理事会;

关键词：

basal cell carcinoma; melanoma; niacinamide; squamous cell carcinoma; vitamin B-3; RADIATION-INDUCED IMMUNOSUPPRESSION; INDUCED DNA-DAMAGE; HIGH-DOSE NICOTINAMIDE; ULTRAVIOLET-RADIATION; PYRIMIDINE DIMERS; REPAIR; RISK; PHOTOCARCINOGENESIS; PREVENTION; NIACIN;

D O I：

10.1111/ajd.12631

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Nicotinamide (vitamin B-3) has a range of photoprotective effects in vitro and in vivo; it enhances DNA repair, reduces UV radiation-induced suppression of skin immune responses, modulates inflammatory cytokine production and skin barrier function and restores cellular energy levels after UV exposure. Pharmacological doses of nicotinamide have been shown to reduce actinic keratoses and nonmelanoma skin cancer incidence in high-risk individuals, making this a nontoxic and accessible option for skin cancer chemoprevention in this population.

引用

页码：174 / 180

页数：7

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