Enhanced cellular osteogenic differentiation on Zn-containing bioglass incorporated TiO2 nanorod films

被引：3

作者：

He, Meng ^{[1
]}

Chen, Xiaoyi ^{[2
]}

Cheng, Kui ^{[1
]}

Dong, Lingqing ^{[2
]}

Weng, Wenjian ^{[1
]}

Wang, Huiming ^{[2
]}

机构：

[1] Zhejiang Univ, Sch Mat Sci & Engn, State Key Lab Silicon Mat, Hangzhou, Zhejiang, Peoples R China

[2] Zhejiang Univ, Sch Med, Affiliated Stomatol Hosp, Hangzhou, Zhejiang, Peoples R China

来源：

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE | 2018年 / 29卷 / 09期

基金：

中国国家自然科学基金;

关键词：

MESENCHYMAL STEM-CELLS; BIOACTIVE GLASSES; IN-VITRO; SURFACE FUNCTIONALIZATION; BIOLOGICAL SIGNIFICANCE; NATURAL MOLECULES; BONE-FORMATION; ZINC; TITANIUM; GROWTH;

D O I：

10.1007/s10856-018-6141-6

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Surface nanotopography and bioactive ions have been considered to play critical roles on the interactions of biomaterials with cells. In this study, a TiO2 nanorod film incorporated with Zn-containing bioactive glass (TiO2/Zn-BG) was prepared on tantalum substrate, trying to evaluate the synergistic effects of nanotopograpgy and bioactive ions to promote cellular osteogenic differentiation activity. The expression of osteogenic-related genes, ALP as well as the ECM mineralization on TiO2/Zn-BG film were significantly upregulated compared to that of the film without TiO2 nanorod nanostructure (Zn-BG) or without Zn (TiO2/BG). Moreover, a much low Zn2+ release level on TiO2/Zn-BG film was beneficial to promote the osteogenesis, which could be ascribed to that a semi-closed space established by TiO2 nanorods with adhered cells provided an appropriate micro-environment that facilitated Zn2+ adsorption. [GRAPHICS] .

引用

页数：9

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