A Mild Synthesis of 2-Substituted Benzothiazoles via Nickel-Catalyzed Intramolecular Oxidative C-H Functionalization

被引：41

作者：

Gao, Ming-Yuan ^{[2
]}

Li, Jing-Hang ^{[2
]}

Zhang, Shi-Bo ^{[2
]}

Chen, Li Jun ^{[2
]}

Li, Yue-Sheng ^{[1
]}

Dong, Zhi-Bing ^{[1
,2
]}

机构：

[1] Hubei Univ Sci & Technol, Hubei Key Lab Radiat Chem & Funct Mat, Sch Nucl Technol & Chem & Biol, Xianning 437100, Peoples R China

[2] Wuhan Inst Technol, Sch Chem & Environm Engn, Wuhan 430205, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2020年 / 85卷 / 02期

关键词：

METAL-FREE SYNTHESIS; S BOND FORMATION; COUPLING REACTIONS; CASCADE REACTIONS; 2-AMINOBENZOTHIAZOLES; DERIVATIVES; CYCLIZATION;

D O I：

10.1021/acs.joc.9b02543

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly efficient synthetic method for the preparation of 2-aminobenzothiazoles starting from arylthioureas has been reported. By using a nickel catalyst, arylthioureas undergo intramolecular oxidative C-H bond functionalization, giving the desired 2-aminobenzothiazoles in good to excellent yields. This protocol features an inexpensive catalyst, low catalyst loading, mild reaction conditions, a short reaction time, and good to excellent yields, and it can be scaled up easily to a gram scale with almost no yields decreasing.

引用

页码：493 / 500

页数：8

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