Extracellular Matrix and Cancer-associated Fibroblasts

被引：0
作者：
Gao Yuan [1 ]
Wu Yue-Xin [1 ]
Han Ying-Ying [1 ]
Ge Gao-Xiang [1 ]
机构：
[1] Chinese Acad Sci, CAS Ctr Excellence Mol Cell Sci, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China
来源：
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS | 2017年 / 44卷 / 08期
基金：
中国国家自然科学基金;
关键词：
cancer; microenvironment; desmoplasia; cancer-associated fibroblasts; extracellular matrix; CARCINOMA-ASSOCIATED FIBROBLASTS; GROWTH-FACTOR; LYSYL OXIDASE; TUMOR STROMA; TGF-BETA; HUMAN BREAST; TENASCIN-C; STEM-CELLS; ANGIOGENESIS; FIBROSIS;
D O I：
10.16476/j.pibb.2017.0251
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cancer progression and metastasis are the result of reciprocal interaction between cancer cells and the surrounding stromal components. Tumor stroma features with activation of fibroblasts to cancer-associated fibroblasts (CAFs) and active remodeling of extracellular matrix (ECM) in most solid tumors. CAFs and ECM remodeling are not only characteristics of malignant tumors, but also actively promote tumor progression and metastasis through multiple mechanisms. Strategies targeting CAFs and ECM remodeling may provide novel and powerful approaches in cancer therapeutics.
引用
收藏
页码：660 / 671
页数：12
相关论文
共 124 条
[91]   Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival [J].
Oezdemir, Berna C. ;
Pentcheva-Hoang, Tsvetelina ;
Carstens, Julienne L. ;
Zheng, Xiaofeng ;
Wu, Chia-Chin ;
Simpson, Tyler R. ;
Laklai, Hanane ;
Sugimoto, Hikaru ;
Kahlert, Christoph ;
Novitskiy, Sergey V. ;
De Jesus-Acosta, Ana ;
Sharma, Padmanee ;
Heidari, Pedram ;
Mahmood, Umar ;
Chin, Lynda ;
Moses, Harold L. ;
Weaver, Valerie M. ;
Maitra, Anirban ;
Allison, James P. ;
LeBleu, Valerie S. ;
Kalluri, Raghu .
CANCER CELL, 2014, 25 (06) :719-734
[92]  
Olumi AF, 1999, CANCER RES, V59, P5002
[93]   Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion [J].
Orimo, A ;
Gupta, PB ;
Sgroi, DC ;
Arenzana-Seisdedos, F ;
Delaunay, T ;
Naeem, R ;
Carey, VJ ;
Richardson, AL ;
Weinberg, RA .
CELL, 2005, 121 (03) :335-348
[94]   Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs [J].
Oskarsson, Thordur ;
Acharyya, Swarnali ;
Zhang, Xiang H-F ;
Vanharanta, Sakari ;
Tavazoie, Sohail F. ;
Morris, Patrick G. ;
Downey, Robert J. ;
Manova-Todorova, Katia ;
Brogi, Edi ;
Massague, Joan .
NATURE MEDICINE, 2011, 17 (07) :867-U256
[95]   Transforming Growth Factor-β Signaling Curbs Thymic Negative Selection Promoting Regulatory T Cell Development [J].
Ouyang, Weiming ;
Beckett, Omar ;
Ma, Qian ;
Li, Ming O. .
IMMUNITY, 2010, 32 (05) :642-653
[96]   β1 integrin inhibitory antibody induces apoptosis of breast cancer cells, inhibits growth, and distinguishes malignant from normal phenotype in three dimensional cultures and in vivo [J].
Park, CC ;
Zhang, H ;
Paravicini, M ;
Gray, JW ;
Baehner, F ;
Park, CJ ;
Bissell, MJ .
CANCER RESEARCH, 2006, 66 (03) :1526-1535
[97]   Tensional homeostasis and the malignant phenotype [J].
Paszek, MJ ;
Zahir, N ;
Johnson, KR ;
Lakins, JN ;
Rozenberg, GI ;
Gefen, A ;
Reinhart-King, CA ;
Margulies, SS ;
Dembo, M ;
Boettiger, D ;
Hammer, DA ;
Weaver, VM .
CANCER CELL, 2005, 8 (03) :241-254
[98]   Functions of paracrine PDGF signaling in the proangiogenic tumor stroma revealed by pharmacological targeting [J].
Pietras, Kristian ;
Pahler, Jessica ;
Bergers, Gabriele ;
Hanahan, Douglas .
PLOS MEDICINE, 2008, 5 (01) :123-138
[99]   The Role of the Microenvironment in Mammary Gland Development and Cancer [J].
Polyak, Kornelia ;
Kalluri, Raghu .
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY, 2010, 2 (11) :a003244
[100]   Co-evolution of tumor cells and their microenvironment [J].
Polyak, Kornelia ;
Haviv, Izhak ;
Campbell, Ian G. .
TRENDS IN GENETICS, 2009, 25 (01) :30-38
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