Extracellular Matrix and Cancer-associated Fibroblasts

被引：0
作者：
Gao Yuan [1 ]
Wu Yue-Xin [1 ]
Han Ying-Ying [1 ]
Ge Gao-Xiang [1 ]
机构：
[1] Chinese Acad Sci, CAS Ctr Excellence Mol Cell Sci, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China
来源：
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS | 2017年 / 44卷 / 08期
基金：
中国国家自然科学基金;
关键词：
cancer; microenvironment; desmoplasia; cancer-associated fibroblasts; extracellular matrix; CARCINOMA-ASSOCIATED FIBROBLASTS; GROWTH-FACTOR; LYSYL OXIDASE; TUMOR STROMA; TGF-BETA; HUMAN BREAST; TENASCIN-C; STEM-CELLS; ANGIOGENESIS; FIBROSIS;
D O I：
10.16476/j.pibb.2017.0251
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cancer progression and metastasis are the result of reciprocal interaction between cancer cells and the surrounding stromal components. Tumor stroma features with activation of fibroblasts to cancer-associated fibroblasts (CAFs) and active remodeling of extracellular matrix (ECM) in most solid tumors. CAFs and ECM remodeling are not only characteristics of malignant tumors, but also actively promote tumor progression and metastasis through multiple mechanisms. Strategies targeting CAFs and ECM remodeling may provide novel and powerful approaches in cancer therapeutics.
引用
收藏
页码：660 / 671
页数：12
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