The relationship between FENO and effectiveness of mepolizumab and benralizumab in severe eosinophilic asthma

被引：56

作者：

Hearn, Andrew P. ^{[1
,2
]}

Kavanagh, Joanne ^{[1
,2
]}

d'Ancona, Grainne ^{[1
]}

Roxas, Cris ^{[1
]}

Green, Linda ^{[1
]}

Thomson, Louise ^{[1
]}

Fernandes, Marianna ^{[1
]}

Kent, Brian D. ^{[1
,3
,4
]}

Dhariwal, Jaideep ^{[1
]}

Nanzer, Alexanda M. ^{[1
]}

Jackson, David J. ^{[1
,2
]}

机构：

[1] Guys & St Thomas NHS Trust, Guys Hosp, Guys Severe Asthma Ctr, London, England

[2] Kings Coll London, Sch Immunol & Microbial Sci, London, England

[3] St James Hosp, Dept Resp Med, Dublin, Ireland

[4] Trinity Coll Dublin, Sch Med, Dublin, Ireland

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE | 2021年 / 9卷 / 05期

关键词：

PLACEBO;

D O I：

10.1016/j.jaip.2021.01.008

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

[No abstract available]

引用

页码：2093 / +

页数：5

共 9 条

[1] Dupilumab Efficacy and Safety in Moderate-to-Severe Uncontrolled Asthma [J].

Castro, M. ;

Corren, J. ;

Pavord, I. D. ;

Maspero, J. ;

Wenzel, S. ;

Rabe, K. F. ;

Busse, W. W. ;

Ford, L. ;

Sher, L. ;

FitzGerald, J. M. ;

Katelaris, C. ;

Tohda, Y. ;

Zhang, B. ;

Staudinger, H. ;

Pirozzi, G. ;

Amin, N. ;

Ruddy, M. ;

Akinlade, B. ;

Khan, A. ;

Chao, J. ;

Martincova, R. ;

Graham, N. M. H. ;

Hamilton, J. D. ;

Swanson, B. N. ;

Stahl, N. ;

Yancopoulos, G. D. ;

Teper, A. .

NEW ENGLAND JOURNAL OF MEDICINE, 2018, 378 (26) :2486-2496

[2] Benralizumab, an anti-interleukin 5 receptor α monoclonal antibody, versus placebo for uncontrolled eosinophilic asthma: a phase 2b randomised dose-ranging study [J].

Castro, Mario ;

Wenzel, Sally E. ;

Bleecker, Eugene R. ;

Pizzichini, Emilio ;

Kuna, Piotr ;

Busse, William W. ;

Gossage, David L. ;

Ward, Christine K. ;

Wu, Yanping ;

Wang, Bing ;

Khatry, Deepak B. ;

van der Merwe, Rene ;

Kolbeck, Roland ;

Molfino, Nestor A. ;

Raible, Donald G. .

LANCET RESPIRATORY MEDICINE, 2014, 2 (11) :879-890

[3] Mepolizumab and Exacerbations of Refractory Eosinophilic Asthma [J].

Haldar, Pranabashis ;

Brightling, Christopher E. ;

Hargadon, Beverley ;

Gupta, Sumit ;

Monteiro, William ;

Sousa, Ana ;

Marshall, Richard P. ;

Bradding, Peter ;

Green, Ruth H. ;

Wardlaw, Andrew J. ;

Pavord, Ian D. .

NEW ENGLAND JOURNAL OF MEDICINE, 2009, 360 (10) :973-984

[4] Real World Effectiveness of Benralizumab in Severe Eosinophilic Asthma (vol 159, pg 496, 2022) [J].

不详 .

CHEST, 2023, 163 (05) :1340-1340

[5] Real-World Effectiveness and the Characteristics of a "Super-Responder" to Mepolizumab in Severe Eosinophilic Asthma [J].

Kavanagh, Joanne E. ;

d'Ancona, Grainne ;

Elstad, Maria ;

Green, Linda ;

Fernandes, Mariana ;

Thomson, Louise ;

Roxas, Cris ;

Dhariwal, Jaideep ;

Nanzer, Alexandra M. ;

Kent, Brian D. ;

Jackson, David J. .

CHEST, 2020, 158 (02) :491-500

[6] The Cytokines of Asthma [J].

Lambrecht, Bart N. ;

Hammad, Hamida ;

Fahy, John V. .

IMMUNITY, 2019, 50 (04) :975-991

[7] Role of myeloid cells in the regulation of group 2 innate lymphoid cell-mediated allergic inflammation [J].

Lei, Aihua ;

He, Yumei ;

Yang, Qiong ;

Li, Xiaofang ;

Li, Ranhui .

IMMUNOLOGY, 2020, 161 (01) :18-24

[8] Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial [J].

Pavord, Ian D. ;

Korn, Stephanie ;

Howarth, Peter ;

Bleecker, Eugene R. ;

Buhl, Roland ;

Keene, Oliver N. ;

Ortega, Hector ;

Chanez, Pascal .

LANCET, 2012, 380 (9842) :651-659

[9] Eosinophils express functional IL-13 in eosinophilic inflammatory diseases [J].

Schmid-Grendelmeier, P ;

Altznauer, F ;

Fischer, B ;

Bizer, C ;

Straumann, A ;

Menz, G ;

Blaser, K ;

Wüthrich, B ;

Simon, HU .

JOURNAL OF IMMUNOLOGY, 2002, 169 (02) :1021-1027

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