Linking metabolic reprogramming to therapy resistance in cancer

被引：129

作者：

Morandi, Andrea ^{[1
]}

Indraccolo, Stefano ^{[2
]}

机构：

[1] Univ Florence, Dept Expt & Clin Biomed Sci, Viale GB Morgagni 50, I-50134 Florence, Italy

[2] IRCCS, Ist Oncol Veneto, Via Gattamelata 64, I-35128 Padua, Italy

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 2017年 / 1868卷 / 01期

关键词：

Metabolic reprogramming; Warburg metabolism; OXPHOS; Therapy resistance; DRUG-RESISTANCE; BREAST-CANCER; OXIDATIVE-PHOSPHORYLATION; GLUCOSE-METABOLISM; IN-VIVO; CELLS; INHIBITION; CISPLATIN; DETERMINANT; ACID;

D O I：

10.1016/j.bbcan.2016.12.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Metabolic rearrangements are essential to satisfy the different requirements of cancer cells during tumorigenesis and recent studies have highlighted a role for such metabolic reprogramming in response and adaptation to therapies. However, therapy-resistant experimental models have been described to be either glycolysis-dependent or OXPHOS-addicted. Here we discuss the recent literature on metabolic reprogramming of cancer in therapy resistance with a plausible explanation of the observed differences which collectively indicate that dis-regulated metabolic pathways could be considered potential therapeutic targets in tumors resistant to conventional therapy. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：1 / 6

页数：6

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