c-Met antisense oligodeoxynucleotides increase sensitivity of human glioma cells to paclitaxel

被引：13

作者：

Chu, Sheng-Hua ^{[1
]}

Ma, Yan-Bin ^{[1
]}

Feng, Dong-Fu ^{[1
]}

Zhang, Hong ^{[1
]}

Qiu, Jian-Hua ^{[1
]}

Zhu, Zhi-An ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Dept Neurosurg, Peoples Hosp Affiliated 3, Sch Med, Shanghai 201900, Peoples R China

来源：

ONCOLOGY REPORTS | 2010年 / 24卷 / 01期

关键词：

antisense oligonucleotide; apoptosis; c-Met; glioma; paclitaxel; IN-VITRO; MALIGNANT GLIOMA; LUNG-CANCER; PHASE-II; RADIATION; GROWTH; CARCINOMA; ARREST; VIVO;

D O I：

10.3892/or_00000845

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cell culture, tissue chemistry and flow cytometry were used to determine whether antisense c-Met oligodeoxynucleotides enhanced the sensitivity of human glioma cells to paclitaxel. A combination of paclitaxel with antisense c-Met oligodeoxynucleotides inhibited cell growth, induced apoptosis and induced c-Met protein expression in U251 and SHG44 human glioma cells more significantly than either paclitaxel or the oligodeoxynucleotides on their own (P<0.01). Thus, c-Met antisense oligodeoxynucleotides increase the sensitivity of human glioma cells to paclitaxel. Combined use of the two agents could be a novel and attractive strategy in human glioma treatment.

引用

页码：189 / 194

页数：6

共 27 条

[1]

[Anonymous], J MED FORUM

[2] Distribution and stability of antisense phosphorothioate oligonucleotides in rodent brain following direct intraparenchymal controlled-rate infusion [J].