Non-apoptotic Caspase regulation of stem cell properties

被引:37
作者
Baena-Lopez, Luis Alberto [1 ]
Arthurton, Lewis [1 ]
Xu, Derek Cui [1 ]
Galasso, Alessia [1 ]
机构
[1] Univ Oxford, Sir William Dunn Sch Pathol, Oxford OX1 3RE, England
关键词
Apoptosis; Caspases; Caspase treatment; Non-apoptotic functions; Stem cell; THERAPEUTIC TARGETS; ACTIVE CASPASE-3; IN-VIVO; DIFFERENTIATION; PROLIFERATION; ACTIVATION; DROSOPHILA; CLEAVAGE; ROLES; DEATH;
D O I
10.1016/j.semcdb.2017.10.034
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The evolutionarily conserved family of proteins called caspases are the main factors mediating the orchestrated programme of cell suicide known as apoptosis. Since this protein family was associated with this essential biological function, the majority of scientific efforts were focused towards understanding their molecular activation and function during cell death. However, an emerging body of evidence has highlighted a repertoire of non-lethal roles within a large variety of cell types, including stem cells. Here we intend to provide a comprehensive overview of the key role of caspases as regulators of stem cell properties. Finally, we briefly discuss the possible pathological consequences of caspase malfunction in stem cells, and the therapeutic potential of caspase regulation applied to this context. (C) 2017 The Authors. Published by Elsevier Ltd.
引用
收藏
页码:118 / 126
页数:9
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