Poly(ADP-ribose) polymerase inhibitors as potential chemotherapeutic agents

被引：45

作者：

Bryant, HE ^{[1
]}

Helleday, T ^{[1
]}

机构：

[1] Univ Sheffield, Inst Canc Studies, Sheffield S10 2RX, S Yorkshire, England

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2004年 / 32卷

关键词：

cancer treatment; DNA repair; homologous recombination; poly(ADP-ribose) polymerase; replication;

D O I：

10.1042/BST0320959

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

PARP [poly(ADP-ribose) polymerase] activity is up-regulated by binding to DNA strand breaks and its association with DNA repair is well documented. many anticancer therapies work by inducing breaks in DNA, if unrepaired these can lead to cell death. As PARP promotes DNA repair there is a strong rational to suggest that its inhibition may increase the efficiency of certain cytotoxic treatments. This review discusses the advances made in PARP inhibitor design and the mechanism by which they enhance anti-tumour therapies.

引用

页码：959 / 961

页数：3

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