The Present and Future of Allergen Immunotherapy in Personalized Medicine

被引：17

作者：

Ridolo, Erminia ^{[1
]}

Incorvaia, Cristoforo ^{[1
]}

Heffler, Enrico ^{[2
,3
]}

Cavaliere, Carlo ^{[4
]}

Paoletti, Giovanni ^{[2
,3
]}

Canonica, Giorgio Walter ^{[2
,3
]}

机构：

[1] Univ Parma, Dept Med & Surg, Allergy & Clin Immunol, I-43121 Parma, Italy

[2] IRCCS Humanitas Res Hosp, I-20089 Milan, Italy

[3] Humanitas Univ, Dept Biomed Sci, I-20089 Milan, Italy

[4] Sapienza Univ, Dept Sense Organs, I-00185 Rome, Italy

来源：

JOURNAL OF PERSONALIZED MEDICINE | 2022年 / 12卷 / 05期

关键词：

personalized medicine; omics; allergen immunotherapy; RHINITIS PATIENTS; MECHANISMS; EFFICACY;

D O I：

10.3390/jpm12050774

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

Allergic diseases are particularly suitable for personalized medicine, because they meet the needs for therapeutic success, which include a known molecular mechanism of the disease, a diagnostic tool for that disease and a treatment that blocks this mechanism. A range of tools is available for personalized allergy diagnosis, including molecular diagnostics, treatable traits and omics (i.e., proteomics, epigenomics, metabolomics, transcriptomics and breathomics), to predict patient response to therapies, detect biomarkers and mediators and assess disease control status. Such tools enhance allergen immunotherapy. Higher diagnostic accuracy results in a significant increase (based on a greater performance achieved with personalized treatment) in efficacy, further increasing the known and unique characteristics of a treatment designed to work on allergy causes.

引用

页数：9

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