Coenzyme Q treatment of neurodegenerative diseases of aging

被引：55
作者：
Galpern, Wendy R.
Cudkowicz, Merit E.
机构：
[1] NINDS, NIH, Bethesda, MD 20892 USA
[2] Massachusetts Gen Hosp E, Neurol Clin Trials Unit, Charlestown, MA 02129 USA
来源：
MITOCHONDRION | 2007年 / 7卷
关键词：
amyotrophic lateral sclerosis; Parkinson's disease; Huntington's disease; coenzyme Q; clinical trial;
D O I：
10.1016/j.mito.2007.01.004
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The etiology of several neurodegenerative disorders is thought to involve impaired mitochondrial function and oxidative stress. Coenzyme Q-10 (CoQ(10)) acts both as an antioxidant and as an electron acceptor at the level of the mitochondria. In several animal models of neurodegenerative diseases including amyotrophic lateral sclerosis, Huntington's disease, and Parkinson's disease, CoQ(10) has shown beneficial effects. Based on its biochemical properties and the effects in animal models, several clinical trials evaluating CoQ(10) have been undertaken in many neurodegenerative diseases. CoQ(10) appears to be safe and well tolerated, and several efficacy trials are planned. (c) 2007 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
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收藏
页码：S146 / S153
页数：8
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