Single all-fiber-based nanosecond-pulsed supercontinuum source for multispectral photoacoustic microscopy and optical coherence tomography

被引:37
作者
Shu, Xiao [1 ]
Bondu, Magalie [2 ,3 ]
Dong, Biqin [1 ]
Podoleanu, Adrian [2 ]
Leick, Lasse [3 ]
Zhang, Hao F. [1 ,4 ]
机构
[1] Northwestern Univ, Dept Biomed Engn, Evanston, IL 60208 USA
[2] Univ Kent, Sch Phys Sci, Appl Opt Grp, Canterbury CT2 7NH, Kent, England
[3] NKT Photon AS, DK-3460 Birkerod, Denmark
[4] Northwestern Univ, Dept Ophthalmol, Chicago, IL 60611 USA
基金
美国国家科学基金会; 美国国家卫生研究院;
关键词
D O I
10.1364/OL.41.002743
中图分类号
O43 [光学];
学科分类号
070207 ; 0803 ;
摘要
We report the usefulness of a single all-fiber-based supercontinuum (SC) source for combined photoacoustic microscopy (PAM) and optical coherence tomography (OCT). The SC light is generated by a tapered photonic crystal fiber pumped by a nanosecond pulsed master oscillator power amplifier at 1064 nm. The spectrum is split into a shorter wavelength band (500-800 nm) for single/multi-spectral PAM and a longer wavelength band (800-900 nm) band for OCT. In vivo mouse ear imaging was achieved with an integrated dual-modality system. We further demonstrated its potential for spectroscopic photoacoustic imaging by doing multispectral measurements on retinal pigment epithelium and blood samples with 15-nm line-width. (C) 2016 Optical Society of America
引用
收藏
页码:2743 / 2746
页数:4
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