Single all-fiber-based nanosecond-pulsed supercontinuum source for multispectral photoacoustic microscopy and optical coherence tomography

被引：41

作者：

Shu, Xiao ^{[1
]}

Bondu, Magalie ^{[2
,3
]}

Dong, Biqin ^{[1
]}

Podoleanu, Adrian ^{[2
]}

Leick, Lasse ^{[3
]}

Zhang, Hao F. ^{[1
,4
]}

机构：

[1] Northwestern Univ, Dept Biomed Engn, Evanston, IL 60208 USA

[2] Univ Kent, Sch Phys Sci, Appl Opt Grp, Canterbury CT2 7NH, Kent, England

[3] NKT Photon AS, DK-3460 Birkerod, Denmark

[4] Northwestern Univ, Dept Ophthalmol, Chicago, IL 60611 USA

来源：

OPTICS LETTERS | 2016年 / 41卷 / 12期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

D O I：

10.1364/OL.41.002743

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

We report the usefulness of a single all-fiber-based supercontinuum (SC) source for combined photoacoustic microscopy (PAM) and optical coherence tomography (OCT). The SC light is generated by a tapered photonic crystal fiber pumped by a nanosecond pulsed master oscillator power amplifier at 1064 nm. The spectrum is split into a shorter wavelength band (500-800 nm) for single/multi-spectral PAM and a longer wavelength band (800-900 nm) band for OCT. In vivo mouse ear imaging was achieved with an integrated dual-modality system. We further demonstrated its potential for spectroscopic photoacoustic imaging by doing multispectral measurements on retinal pigment epithelium and blood samples with 15-nm line-width. (C) 2016 Optical Society of America

引用

页码：2743 / 2746

页数：4

共 14 条

[1] Spectroscopic photoacoustic microscopy using a photonic crystal fiber supercontinuum source [J].

Billeh, Yazan N. ;

Liu, Mengyang ;

Buma, Takashi .

OPTICS EXPRESS, 2010, 18 (18) :18519-18524

[2] High energy supercontinuum sources using tapered photonic crystal fibers for multispectral photoacoustic microscopy [J].

Bondu, Magalie ;

Brooks, Christopher ;

Jakobsen, Christian ;

Oakes, Keith ;

Moselund, Peter Morten ;

Leick, Lasse ;

Bang, Ole ;

Podoleanu, Adrian .

JOURNAL OF BIOMEDICAL OPTICS, 2016, 21 (06)

[3] Noise characterization of supercontinuum sources for low-coherence interferometry applications [J].

Brown, William J. ;

Kim, Sanghoon ;

Wax, Adam .

JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION, 2014, 31 (12) :2703-2710

[4] Multispectral photoacoustic microscopy based on an optical-acoustic objective [J].

Cao, Rui ;

Kilroy, Joseph P. ;

Ning, Bo ;

Wang, Tianxiong ;

Hossack, John A. ;

Hu, Song .

PHOTOACOUSTICS, 2015, 3 (02) :55-59

[5] High resolution Fourier domain optical coherence tomography in the 2 μm wavelength range using a broadband supercontinuum source [J].

Cheung, C. S. ;

Daniel, J. M. O. ;

Tokurakawa, M. ;

Clarkson, W. A. ;

Liang, H. .

OPTICS EXPRESS, 2015, 23 (03) :1992-2001

[6] In-vivo functional optical-resolution photoacoustic microscopy with stimulated Raman scattering fiber-laser source [J].

Hajireza, Parsin ;

Forbrich, Alexander ;

Zemp, Roger .

BIOMEDICAL OPTICS EXPRESS, 2014, 5 (02) :539-546

[7] Combined photoacoustic and optical coherence tomography using a single near-infrared supercontinuum laser source [J].

Lee, Changho ;

Han, Seunghoon ;

Kim, Sehui ;

Jeon, Mansik ;

Jeon, Min Yong ;

Kim, Chulhong ;

Kim, Jeehyun .

APPLIED OPTICS, 2013, 52 (09) :1824-1828

[8] Three-dimensional combined photoacoustic and optical coherence microscopy for in vivo microcirculation studies [J].

Li, Li ;

Maslov, Konstantin ;

Ku, Geng ;

Wang, Lihong V. .

OPTICS EXPRESS, 2009, 17 (19) :16450-16455

[9] Monte Carlo investigation on quantifying the retinal pigment epithelium melanin concentration by photoacoustic ophthalmoscopy [J].

Shu, Xiao ;

Liu, Wenzhong ;

Zhang, Hao F. .

JOURNAL OF BIOMEDICAL OPTICS, 2015, 20 (10)

[10] A combined method to quantify the retinal metabolic rate of oxygen using photoacoustic ophthalmoscopy and optical coherence tomography [J].

Song, Wei ;

Wei, Qing ;

Liu, Wenzhong ;

Liu, Tan ;

Yi, Ji ;

Sheibani, Nader ;

Fawzi, Amani A. ;

Linsenmeier, Robert A. ;

Jiao, Shuliang ;

Zhang, Hao F. .

SCIENTIFIC REPORTS, 2014, 4

← 1 2 →