Dehydrogenation Based Asymmetric Epoxidation of Arylalkanes to Chiral Epoxides

被引：10

作者：

Su, Yiting ^{[1
]}

Yu, Feng ^{[1
]}

Liu, Guixia ^{[2
]}

Huang, Zheng ^{[1
,2
,3
]}

机构：

[1] East China Normal Univ, Chang Kung Chuang Inst, Shanghai 200062, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Organ Chem, Ctr Excellence Mol Synth, State Key Lab Organometall Chem, 345 Lingling Rd, Shanghai 200032, Peoples R China

[3] Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Chem & Mat Sci, 1 Sublane Xiangshan, Hangzhou 310024, Zhejiang, Peoples R China

来源：

CHINESE JOURNAL OF CHEMISTRY | 2022年 / 40卷 / 19期

基金：

国家重点研发计划; 中国国家自然科学基金;

关键词：

Alkanes; Asymmetric epoxidation; Dehydrogenation; Dual-catalysts; Iridium; ALKANE METATHESIS; FUNCTIONALIZATION; AZIRIDINATION; CONVERSION; DARZENS; H2O2;

D O I：

10.1002/cjoc.202200304

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Comprehensive Summary We report herein a formal asymmetric epoxidation of arylalkanes enabled by a one-pot dual-catalysts system comprising a pincer Ir catalyst for alkane dehydrogenation-alkene isomerization (AD-ISO) and a chiral ketone catalyst for asymmetric alkene epoxidation. This protocol provides a catalytic method for the synthesis of aryl epoxides in useful yields with high regio- and stereoselectivity directly from readily available alkyl arenes. Stereospecific derivatizations of the epoxidation product allow access to various enantioenriched compounds.

引用

页码：2263 / 2268

页数：6

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