Reduced neurite density in the brain and cervical spinal cord in relapsing-remitting multiple sclerosis: A NODDI study

被引：47

作者：

Collorone, Sara ^{[1
]}

Cawley, Niamh ^{[1
]}

Grussu, Francesco ^{[1
,2
]}

Prados, Ferran ^{[1
,2
]}

Tona, Francesca ^{[1
]}

Calvi, Alberto ^{[1
,3
]}

Kanber, Baris ^{[2
]}

Schneider, Torben ^{[1
,4
]}

Kipp, Lucas ^{[1
,5
]}

Zhang, Hui ^{[2
]}

Alexander, Daniel C. ^{[2
]}

Thompson, Alan J. ^{[1
]}

Toosy, Ahmed ^{[1
]}

Wheeler-Kingshott, Claudia A. M. Gandini ^{[1
,6
,7
]}

Ciccarelli, Olga ^{[1
,8
]}

机构：

[1] UCL, Fac Brain Sci, Inst Neurol,NMR Res Unit, Dept Neuroinflammat,Queen Sq Multiple Sclerosis C, 1st Floor,Russell Sq House,10-12 Russell Sq, London WC1B 5EH, England

[2] UCL, Dept Comp Sci, CMIC, London, England

[3] Univ Milan, Fdn IRCCS Osped Maggiore Policlin Mangiagalli & R, Dept Pathophysiol & Transplantat, Neurodegenerat Dis Unit, Milan, Italy

[4] Philips UK, Guildford, Surrey, England

[5] Stanford Univ, Dept Neurol & Neurol Sci, Stanford MS Ctr, Palo Alto, CA 94304 USA

[6] Univ Pavia, Dept Brain & Behav Sci, Pavia, Italy

[7] IRCCS Mondino Fdn, Brain MRI 3T Res Ctr, Pavia, Italy

[8] Univ Coll London Hosp, Biomed Res Ctr, Natl Inst Hlth Res, London, England

来源：

MULTIPLE SCLEROSIS JOURNAL | 2020年 / 26卷 / 13期

基金：

英国医学研究理事会; 英国工程与自然科学研究理事会;

关键词：

Multiple sclerosis; relapsing-remitting; quantitative MRI; NODDI; diffusion-weighted MRI; axonal loss; IN-VIVO; ORIENTATION DISPERSION; GREY-MATTER; SEGMENTATION; PATHOLOGY; IMAGES;

D O I：

10.1177/1352458519885107

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: Multiple sclerosis (MS) affects both brain and spinal cord. However, studies of the neuraxis with advanced magnetic resonance imaging (MRI) are rare because of long acquisition times. We investigated neurodegeneration in MS brain and cervical spinal cord using neurite orientation dispersion and density imaging (NODDI). Objective: The aim of this study was to investigate possible alterations, and their clinical relevance, in neurite morphology along the brain and cervical spinal cord of relapsing-remitting MS (RRMS) patients. Methods: In total, 28 RRMS patients and 20 healthy controls (HCs) underwent brain and spinal cord NODDI at 3T. Physical and cognitive disability was assessed. Individual maps of orientation dispersion index (ODI) and neurite density index (NDI) in brain and spinal cord were obtained. We examined differences in NODDI measures between groups and the relationships between NODDI metrics and clinical scores using linear regression models adjusted for age, sex and brain tissue volumes or cord cross-sectional area (CSA). Results: Patients showed lower NDI in the brain normal-appearing white matter (WM) and spinal cord WM than HCs. In patients, a lower NDI in the spinal cord WM was associated with higher disability. Conclusion: Reduced neurite density occurs in the neuraxis but, especially when affecting the spinal cord, it may represent a mechanism of disability in MS.

引用

页码：1647 / 1657

页数：11

共 35 条

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