Tilescope: online analysis pipeline for high-density tiling microarray data

被引：28

作者：

Zhang, Zhengdong D. ^{[1
]}

Rozowsky, Joel

Lam, Hugo Y. K.

Du, Jiang

Snyder, Michael

Gerstein, Mark

机构：

[1] Yale Univ, Dept Mol Biophys & Biochem, New Haven, CT 06520 USA

[2] Yale Univ, Interdept Program Computat Biol & Bioinformat, New Haven, CT 06520 USA

[3] Yale Univ, Dept Comp Sci, New Haven, CT 06520 USA

[4] Yale Univ, Dept Mol Cellular & Dev Biol, New Haven, CT 06520 USA

来源：

GENOME BIOLOGY | 2007年 / 8卷 / 05期

关键词：

high-density tiling microarray; high-density oligonucleotide microarray; microarray data analysis;

D O I：

10.1186/gb-2007-8-5-r81

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We developed Tilescope, a fully integrated data processing pipeline for analyzing high-density tiling-array data (http://tilescope.gersteinlab.org). In a completely automated fashion, Tilescope will normalize signals between channels and across arrays, combine replicate experiments, score each array element, and identify genomic features. The program is designed with a modular, three-tiered architecture, facilitating parallelism, and a graphic user-friendly interface, presenting results in an organized web page, downloadable for further analysis.

引用

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