New aspects concerning the mode of action of methylphenidate

被引：0
作者：
Krause, K-H. [1 ]
Krause, J. [1 ]
机构：
[1] Univ Munich, Neurol Klin, Friedrich Baur Inst, D-80336 Munich, Germany
来源：
NERVENHEILKUNDE | 2010年 / 29卷 / 1-2期
关键词：
Methylphenidate; mode of action; neurotransmitter; NOREPINEPHRINE TRANSPORTER GENE; DEFICIT HYPERACTIVITY DISORDER; STRIATAL DOPAMINE TRANSPORTER; DEFICIT/HYPERACTIVITY DISORDER; PREFRONTAL CORTEX; ADULT PATIENTS; ATOMOXETINE;
D O I：
暂无
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Until now it has been assumed, that methyl-phenidate (MPH) exerts its action preferably on dopamine metabolism; a blockade of striatal dopamine transporter by MPH with the consequence of an elevation of dopamine in the synaptic cleft has been described. Meanwhile results have been presented, whereupon MPH also blocks the norepinephrine transporter, thus influencing dopamine and norepinephrine metabolism especially in frontal regions. Further investigations showed an influence of MPH also on acetylcholine and histamine. In contrast to amphetamine, methamphetamine, cocaine and MDMA (Ecstasy), MPH seems not to effect the serotonine transporter in a remarkable extent.
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页码：35 / 37
页数：3
相关论文
共 17 条
  • [1] Quantitative analysis of norepinephrine transporter in the human brain using PET with (S,S)-18F-FMeNER-D2
    Arakawa, Ryosuke
    Okurnura, Masaki
    Ito, Hiroshi
    Seki, Chie
    Takahashi, Hidehiko
    Takano, Harumasa
    Nakao, Ryuji
    Suzuki, Kazutoshi
    Okubo, Yoshiro
    Halldin, Christer
    Suhara, Tetsuya
    [J]. JOURNAL OF NUCLEAR MEDICINE, 2008, 49 (08) : 1270 - 1276
  • [2] Methylphenidate preferentially increases catecholamine neurotransmission within the prefrontal cortex at low doses that enhance cognitive function
    Berridge, Craig W.
    Devilbiss, David M.
    Andrzejewski, Matthew E.
    Arnsten, Amy F. T.
    Kelley, Ann E.
    Schmeichel, Brooke
    Hamilton, Christina
    Spencer, Robert C.
    [J]. BIOLOGICAL PSYCHIATRY, 2006, 60 (10) : 1111 - 1120
  • [3] Brown T., 2000, ATTENTION DEFICIT DI
  • [4] Methylphenidate enhances noradrenergic transmission and suppresses mid- and long-latency sensory responses in the primary somatosensory cortex of awake rats
    Drouin, Candice
    Page, Michelle
    Waterhouse, Barry
    [J]. JOURNAL OF NEUROPHYSIOLOGY, 2006, 96 (02) : 622 - 632
  • [5] GERLACH M, 2004, METHYLPHENIDAT
  • [6] Han Dawn D., 2006, BMC Pharmacology, V6, P6, DOI 10.1186/1471-2210-6-6
  • [7] Methylphenidate and atomoxetine increase histamine release in rat prefrontal cortex
    Horner, Weldon E.
    Johnson, David E.
    Schmidt, Anne W.
    Rollema, Hans
    [J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 2007, 558 (1-3) : 96 - 97
  • [8] Effects of methylphenidate on the membrane potential and current in neurons of the rat locus coeruleus
    Ishimatsu, M
    Kidani, Y
    Tsuda, A
    Akasu, T
    [J]. JOURNAL OF NEUROPHYSIOLOGY, 2002, 87 (03) : 1206 - 1212
  • [9] A polymorphism in the norepinephrine transporter gene alters promoter activity and is associated with attention-deficit hyperactivity disorder
    Kim, Chun-Hyung
    Hahn, Maureen K.
    Joung, Yoosook
    Anderson, Susan L.
    Steele, Angela H.
    Mazei-Robinson, Michelle S.
    Gizer, Ian
    Teicher, Martin H.
    Cohen, Bruce M.
    Robertson, David
    Waldman, Irwin D.
    Blakely, Randy D.
    Kim, Kwang-Soo
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (50) : 19164 - 19169
  • [10] Influence of striatal dopamine transporter availability on the response to methylphenidate in adult patients with ADHD
    Krause, J
    la Fougere, C
    Krause, KH
    Ackenheil, M
    Dresel, SH
    [J]. EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE, 2005, 255 (06) : 428 - 431
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